Table 6 Immunohistochemistry findings in HMH cases. +++: strong staining intensity; ++: moderate staining intensity; +: weak staining intensity; f: focal staining
Case # | Components | Vimentin | HepPar1 | Glypican 3 | Arginase-1 | Desmin | SMA | CD56 | CD10 | CD68 | BCL2 | PD-L1 | C-Kit | CD34 | Ki67 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case 1 | Spindle Cells | +++ | – | – | – | +++ | +++ | ++f | – | – | +f | – | – | – | – |
Hepatocytes | – | +++ | – | ++ | – | – | – | – | – | – | – | – | – | – | |
Bile ducts | – | – | – | – | – | – | +++ | – | – | ++ | – | – | – | – | |
Case2 | Spindle Cells | +++ | – | – | – | +++f | +++f | +f | – | – | ++f | – | – | +++ | – |
Hepatocytes | – | +++ | – | +++ | – | – | – | – | – | – | – | – | – | – | |
Bile ducts | – | – | – | – | – | – | +++ | – | – | ++ | – | – | – | – | |
Case 3 | Spindle Cells | +++ | – | – | – | +++ | +++ | +++ | – | – | +++ | – | – | – | – |
Hepatocytes | – | ++ | +++ | ++ | – | – | – | – | – | – | – | – | – | – | |
Bile ducts | +++ | – | – | – | – | – | +++ | – | – | +++ | – | – | – | – | |
Case 4 | Spindle Cells | +++ | – | – | – | +++ | +++ | ++ | – | – | ++ | – | – | – | – |
Hepatocytes | – | +++ | +++ | +++ | – | – | – | – | – | – | – | – | – | – | |
Bile ducts | +++ | – | – | – | – | – | +++ | – | – | +++ | – | – | – | – | |
Case 5 | Spindle Cells | +++ | – | – | – | +++f | ++ | + | – | – | – | – | – | – | – |
Hepatocytes | – | +++ | +++ | – | – | – | – | – | – | – | – | – | – | – | |
Bile ducts | – | – | – | – | – | – | +++ | – | – | +++ | – | – | – | – | |
Case 7 | Spindle Cells | +++ | – | – | – | – | +++ | + | – | – | – | – | – | – | – |
Hepatocytes | – | +++ | – | ++ | – | – | – | – | – | + | – | – | – | – | |
Bile ducts | – | – | – | – | – | – | +++ | – | – | +++ | – | – | – | – | |
Case 8 | Spindle Cells | +++ | – | – | – | – | +++f | ++ | – | – | – | – | – | +++ | – |
Hepatocytes | – | ++ | – | – | – | – | – | – | – | – | – | – | – | – | |
Bile ducts | – | – | – | – | – | – | +++ | – | – | +++ | – | – | – | – | |
MH/UESL 5 | Spindle Cells | +++ | – | – | – | – | +++ | – | – | – | – | – | – | +++ | – |
Hepatocytes | – | +++ | – | ++ | – | – | – | – | – | – | – | – | – | – | |
Bile ducts | – | – | – | – | – | – | +++ | – | – | ++ | – | – | – | – |