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Table 2 The kidney biopsy pathology and characteristics of the interstitial infiltrating CLL cells

From: The pathological features of leukemic cells infiltrating the renal interstitium in chronic lymphocytic leukemia/small lymphocytic lymphoma from a large single Chinese center

Case Glomerular Interstitium
Light microscopy Immunofluorescence Electron microscopy Light microscopy    Immunofluo-rescence Electron microscopy
  Injury pattern   Electron dense deposits The extent of infiltrate CLL cells Nodular pattern formation Granulomatous   
1 Membranous nephritis IgG++,C3+, C1q+ Subepithelial deposits 10% No No Negative No remarkable change
2 Minor change Negative No deposits 90% Yes No Negative Infiltrating neoplastic cells with crystal formation
3 Focal mesangial and endocapillary proliferative glomerulonephritis C3++ Mesangial and hump-like subepithelial deposits 10% No No Negative No remarkable change
4 Membranoproliferative glomerulonephritis IgG++,IgM+++,C3+,C1q+,κ++,IgG1++,IgG2++ Subendothelial deposits with microtubule formation 10% No No Negative No remarkable change
5 Minor change Negative No deposits 90% Yes Yes Negative No remarkable change
6 Membranoproliferative glomerulonephritis IgG++,C3++,C1q+,κ++IgG1++ Subendothelial and subepithelial deposits with microtubule formation 70% Yes No κ++IgG1++ Infiltrating neoplastic cells with microtubule formation
7 Focal mesangial and endocapillary proliferative glomerulonephritis C3++ Mesangial and hump-like subepithelial deposits 50% Yes No Negative No remarkable change
8 Mesangial proliferative glomerulonephritis and thrombotic microangiopathy C3++ Mesangial and Subendothelial deposits 50% Yes No Negative No remarkable change
9 Glomerular hypertrophy Negative No deposits 20% No No Negative No remarkable change
10 Membranoproliferative glomerulonephritis IgM++,κ++ Subendothelial and mesangial deposits with microtubule formation 50% Yes No IgM++,κ++ No remarkable change