Table 3 Correlation between neuroendocrine marker expression and clinicopathological features in melanoma patients
From: Prognostic significance of the aberrant expression of neuroendocrine markers in melanomas
Clinicopathologic features | CgA (%) | p | Syn (%) | p | CD56 (%) | p | Neuroendocrinea (%) | p |
|---|---|---|---|---|---|---|---|---|
Age (years) | ||||||||
≤ 55 | 6/154 (3.9) | 0.019* | 18/154 (11.7) | 0.078 | 21/92 (22.8) | 0.083 | 32/91 (35.2) | 0.463 |
>55 | 0/150 (0.0) | 8/150 (5.3) | 35/97 (36.1) | 38/97 (39.2) | ||||
Sex | ||||||||
Female | 3/169 (1.8) | 0.539 | 14/168 (8.3) | 1.000 | 34/112 (30.4) | 0.190 | 44/111 (39.6) | 0.170 |
Male | 3/135 (2.2) | 12/136 (8.8) | 22/77 (28.6) | 26/77 (33.8) | ||||
Specimen type | ||||||||
Excision | 5/222 (2.3) | 0.546 | 16/221 (7.2) | 0.353 | 42/137 (30.7) | 0.875 | 49/136 (36.0) | 0.845 |
Biopsy | 1/82 (1.2) | 10/83 (12.0) | 14/52 (26.9) | 21/52 (40.4) | ||||
Origin | ||||||||
Primary | 4/190 (2.1) | 0.893 | 14/190 (7.4) | 0.650 | 36/112 (32.1) | 0.259 | 42/111 (37.8) | 0.304 |
Distant recurrence | 2/110 (1.8) | 12/110 (10.9) | 19/73 (26.0) | 27/73 (40.0) | ||||
Local recurrence | 0/4 (0) | 0/4 (0) | 1/4 (25.0) | 1/3 (33.3) | ||||
Location | ||||||||
Skin | 0/32 (0.0) | 0.147 | 7/32 (21.9) | 0.069 | 6/23 (26.1) | 0.128 | 9/23 (39.1) | 0.309 |
Mucosa | 4/175 (2.3) | 12/175 (6.9) | 40/106 (37.7) | 45/105 (42.9) | ||||
Acral | 2/30 (6.7) | 2/30 (6.7) | 4/19 (21.1) | 7/19 (36.8) | ||||
Other | 0/67 (0.0) | 5/67 (7.5) | 6/41 (14.6) | 9/41 (22.0) | ||||
Histology subtype | ||||||||
Epithelioid | 2/126 (1.6) | 0.272 | 13/126 (10.3) | 0.142 | 23/77 (29.9) | 0.390 | 29/77 (37.7) | 0.662 |
Spindle | 0/17 (0.0) | 1/17 (5.9) | 1/8 (12.5) | 2/8 (25.0) | ||||
Small round cell | 2/96 (2.1) | 5/95 (5.3) | 24/68 (35.3) | 28/67 (41.8) | ||||
Polymorphic | 0/10 (0.0) | 0/10 (0.0) | 1/5 (20.0) | 1/5 (20.0) | ||||
Mix type | 0/23 (0.0) | 0/24 (0.0) | 4/13 (30.8) | 4/13 (30.8) | ||||
Stage | ||||||||
I-II | 4/136 (2.9) | 0.872 | 11/136 (8.1) | 0.106 | 27/86 (31.4) | 0.109 | 34/85 (40.0) | 0.066 |
III | 0/39 (0.0) | 8/39 (20.5) | 10/27 (37.0) | 12/27 (44.4) | ||||
IV | 2/118 (1.7) | 6/118 (5.1) | 14/68 (20.6) | 18/68 (26.5) | ||||