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Table 3 MK ratios in different clinicopathological features

From: Diagnostic performance of Midkine ratios in fine-needle aspirates for evaluation of Cytologically indeterminate thyroid nodules

  MK (ng/ml) P value TG (ng/ml) P value MK/TG (ng/mg) P value FT4(pmol/L) P value MK/FT4(μg/pmol) P value FT4/MK (pmol /μg) P value
Number of nodules   0.392   0.431   0.158   0.449   0.324   0.324
 Solitary 0.47 (0.02,16.93)   5003.25 (155,230,050)   96 (2.10,4021.67)   3.8 (0.33,78.57)   0.1 (0.002,6.84)   9.57 (0.15,563.76)  
 Multiple 0.39 (0.02,12.07)   5711.25 (560,3,224,500)   70.97 (1.52,1202.08)   4.06 (0.48,141.3)   0.07 (0.001,8.21)   14.81 (0.12,910.94)  
aMTD   0.000*   0.691   0.009*   0.395   0.001*   0.001*
  ≤ 1 cm 0.27 (0.013,12.07)   5711.29 (171,230,050)   58.83 (1.52,4021.37)   4.05 (0.54,96.95)   0.06 (0.001,8.21)   17.06 (0.12,910.94)  
 >1 cm,  ≤ 2 cm 0.56 (0.06,16.93)   4119.5 (155,178,100)   161.09 (3.56,2380.22)   3.85 (0.33,80.69)   0.32 (0.004,6.32)   3.16 (0.16,222.71)  
 >2 cm, ≤4 cm 2.50 ± 2.84   8205 (199,3,224,500)   389.81 ± 516.56   2.29 (0.39,141.3)   1.07 ± 1.47   9.53 ± 16.76  
bETE   0.241   0.009*   0.001*   0.009*   0.003*   0.003*
 No invasion 0.37 (0.015,16.93)   9230 (1845,300,500)   40.31 (0.31,1766.59)   6.56 (0.39,332.9)   0.05 (0.001,8.21)   21.92 (0.12,708.99)  
cCapsule and the outside 0.55 (0.02,9.79)   3457.25 (155,3,224,500)   138.95 (2.37,4021.37)   2.73 (0.33,141.3)   0.21 (0.005,6.84)   4.74 (0.15,222.71)  
dSoft tissues or strap muscles 0.35 (0.013,6.42)   3479.75 (1117.519935)   210.42 (3.99,861.67)   5.2 (0.51,96.96)   0.0096 (0.001,6.32)   15.66 (0.16,910.94)  
T stage   0.008*   0.119   0.002*   0.269   0.002*   0.002*
 T1a 0.27 (0.02,12.07)   5807.5 (171,230,050)   60.50 (1.52,4021.37)   3.96 (0.54,89.70)   0.06 (0.001,8.21)   16.63 (0.12,708.99)  
 T1b 0.61 (0.06,16.93)   5003.25 (155,178,100)   137.38 (3.56,2380.22)   4.08 (0.33,80.69)   0.31 (0.005,2.85)   3.24 (0.35,222.71)  
 T2 1.37 (0.30,8.05)   8205 (199,3,224,500)   196.78 (2.37,1766.59)   2.29 (0.39,141.3)   0.59 (0.02,5.00)   1.68 (0.20,56.72)  
 T3b 0.35 (0.11,3.22)   3327.25 (1117.519935)   210.42 (8.82,861.67)   3.05 (0.51,96.96)   0.10 (0.002,6.32)   15.66 (0.16,551.37)  
 T4a 3.22 (0.01,6.42)   6490.5 (3255,9726)   332.18 (3.99,660.37)   9.29 (6.73,11.84)   0.48 (0.001,0.95)   455.99 (1.05,910.94)  
N stage   0.006*   0.635   0.064   0.587   0.025*   0.025*
 N0 0.26 (0.02,9.79)   4645.00 (171.00,230,050.00)   46.35 (1.52,4021.37)   4.53 (0.33,78.50)   0.07 (0.001,6.84)   15.16 (0.15,708.99)  
 N1 0.52 (0.013,16.93)   6162.50 (155.00,3,224,500.00)   111.80 (2.37,2380.22)   3.72 (0.39,141.30)   0.13 (0.001,8.21)   7.94 (0.12,910.94)  
  1. a MTD maximum tumor diameter, b ETE extrathyroidal extension, c capsule and the outside invasion through the capsule and reached the outside, d soft tissues or strap muscles perithyroidal soft tissues or strap muscles
  2. *P<0.05