Table 1 Morphological and immunohistochemical features of normal endometrium and putative CCC precursors
From: Clear cell endometrial carcinoma precursors: presentation of two cases and diagnostic issues
Resting endometrium | Putative low-grade precursors (metaplasia-like) | Putative low-grade precursors (AEH/EIN-like) | Putative high-grade precursor | CC-EIC | Invasive CC-EC | |
|---|---|---|---|---|---|---|
nuclear atypia | none | low-grade | low-grade | high-grade | high-grade | high-grade |
architecture | flat | flat | flat | flat | papillary | solid |
ER, PR | positive | negative | positive | negative | negative | negative |
ki67 | low | moderate (focally high) | moderate | high | high | high |
vimentin | positive | negative | positive | negative | negative | negative |
p16 | weak and patchy | weak/moderate and diffuse | patchy | moderate/strong and diffuse | moderate/strong and diffuse | moderate/strong and diffuse |
p53 | wild-type | wild-type | wild-type | mutant-type | mutant-type | mutant-type |
Napsin A, AMACR | negative | negative | negative | negative | positive | positive |