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Table 1 Morphological and immunohistochemical features of normal endometrium and putative CCC precursors

From: Clear cell endometrial carcinoma precursors: presentation of two cases and diagnostic issues

  Resting endometrium Putative low-grade precursors (metaplasia-like) Putative low-grade precursors (AEH/EIN-like) Putative high-grade precursor CC-EIC Invasive CC-EC
nuclear atypia none low-grade low-grade high-grade high-grade high-grade
architecture flat flat flat flat papillary solid
ER, PR positive negative positive negative negative negative
ki67 low moderate
(focally high)
moderate high high high
vimentin positive negative positive negative negative negative
p16 weak and patchy weak/moderate and diffuse patchy moderate/strong and diffuse moderate/strong and diffuse moderate/strong and diffuse
p53 wild-type wild-type wild-type mutant-type mutant-type mutant-type
Napsin A, AMACR negative negative negative negative positive positive
  1. AEH/EIN Atypical Endometrial Hyperplasia/Endometrioid Intraepithelial Neoplasia, CC-EIC Clear Cell-Endometrial Intraepithelial Carcinoma, CCEC Clear Cell Endometrial Carcinoma