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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Expression of FRS2 in atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: an immunohistochemical analysis of 182 cases with genetic data

Fig. 2

The histologic features of DDLs and corresponding FRS2 FISH and FRS2 immunostaining results. DDL with fibrosarcoma-like differentiation(a), showing FRS2 amplification (inset), displayed 3+ FRS2 immunostaining, exhibiting diffuse and strong cytoplasmic FRS2 expression (b). DDL showing osteosarcoma-like differentiation(c), with FRS2 amplification (inset), had 3+ FRS2 staining, harboring strong FRS2 immunostaining (d). DDL demonstrating undifferentiated sarcoma-like differentiation(e), with FRS2 amplification (inset), harbored 2+ FRS2 staining (f). DDL with leiomyosarcoma-like differentiation(g) harboring FRS2 amplification (inset) showed 1+ positivity for FRS2 immunostaining (h). Red signals represent FRS2. Green signals represent chromosome12 centromeres. (a, c, e, g, haematoxylin and eosin; b, d, f, h, immunostaining) (original magnification a-h × 400)

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Diagnostic Pathology

ISSN: 1746-1596

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