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Table 3 Parameters affecting overall survival in 132 patients with AML/MDS

From: TP53 mutation in newly diagnosed acute myeloid leukemia and myelodysplastic syndrome

AML/ MDS patients AML patients
Factors 1y- OS 3y- OS P Factors 1y- OS 3y- OS P
AML 44 22 0.535 WBC < 100,00/μL 46 27 0.014
MDS 60 27   WBC > 100,00/μL 28 0  
Complex karyotype    < 0.001 Complex karyotype    < 0.001
Yes 17 0   Yes 6 0  
No 54 29   No 51 27  
Monosomy    0.03 Monosomy    0.003
Yes 19 7   Yes 13 6  
No 53 27   No 49 25  
Complex karyotype with monosomy    < 0.001 Complex karyotype with monosomy    0.001
Yes 14 0   Yes 10 0  
No 51 27   No 47 25  
Chromosome    0.004 Chromosome    0.023
Favorable 80 40   Favorable 75 38  
Intermediate 54 28   Intermediate 50 27  
Unfavorable 27 8   Unfavorable 22 11  
TP53    0.001 TP53    0.001
Mutant TP53 14 NA   Mutant TP53 8 0  
Wild- type TP53 50 25   Wild- type TP53 47 25  
Mutated TP53 with complex karyotype    0.001 Mutated TP53 with complex karyotype    0.004
Yes 0 0   Yes 0 0  
No 50 25   No 46 23  
Mutated TP53 with monosomy    0.138 Mutated TP53 with monosomy    0.034
Yes 17 NA   Yes 0 0  
No 48 24   No 45 23  
  1. Abbreviation: NA not available