Table 3 Parameters affecting overall survival in 132 patients with AML/MDS
From: TP53 mutation in newly diagnosed acute myeloid leukemia and myelodysplastic syndrome
AML/ MDS patients | AML patients | ||||||
|---|---|---|---|---|---|---|---|
Factors | 1y- OS | 3y- OS | P | Factors | 1y- OS | 3y- OS | P |
AML | 44 | 22 | 0.535 | WBC < 100,00/μL | 46 | 27 | 0.014 |
MDS | 60 | 27 | WBC > 100,00/μL | 28 | 0 | ||
Complex karyotype | < 0.001 | Complex karyotype | < 0.001 | ||||
Yes | 17 | 0 | Yes | 6 | 0 | ||
No | 54 | 29 | No | 51 | 27 | ||
Monosomy | 0.03 | Monosomy | 0.003 | ||||
Yes | 19 | 7 | Yes | 13 | 6 | ||
No | 53 | 27 | No | 49 | 25 | ||
Complex karyotype with monosomy | < 0.001 | Complex karyotype with monosomy | 0.001 | ||||
Yes | 14 | 0 | Yes | 10 | 0 | ||
No | 51 | 27 | No | 47 | 25 | ||
Chromosome | 0.004 | Chromosome | 0.023 | ||||
Favorable | 80 | 40 | Favorable | 75 | 38 | ||
Intermediate | 54 | 28 | Intermediate | 50 | 27 | ||
Unfavorable | 27 | 8 | Unfavorable | 22 | 11 | ||
TP53 | 0.001 | TP53 | 0.001 | ||||
Mutant TP53 | 14 | NA | Mutant TP53 | 8 | 0 | ||
Wild- type TP53 | 50 | 25 | Wild- type TP53 | 47 | 25 | ||
Mutated TP53 with complex karyotype | 0.001 | Mutated TP53 with complex karyotype | 0.004 | ||||
Yes | 0 | 0 | Yes | 0 | 0 | ||
No | 50 | 25 | No | 46 | 23 | ||
Mutated TP53 with monosomy | 0.138 | Mutated TP53 with monosomy | 0.034 | ||||
Yes | 17 | NA | Yes | 0 | 0 | ||
No | 48 | 24 | No | 45 | 23 | ||