Table 2 Histologic features of intramucosal and submucosal adenocarcinoma
Feature | Intramucosal adenocarcinoma (n = 26)a | Submucosal adenocarcinoma (n = 18)b | |
|---|---|---|---|
Histologic type | Tubuloinfiltrative | 13 (50%) | 8 (44.4%) |
Tubulocystic | 9 (34.6%) | 4 (22.2%) | |
Mixed | 3 (11.5%) | 1 (5.5%) | |
Papillary | 1 (3.8%) | 2 (11.1%) | |
Mixed tubular and Mucinous | 0 (0%) | 2 (11.1%) | |
Mixed tubular and signet ring cell | 0 (0%) | 1 (5.5%) | |
Pure mucinous | 0 (0%) | 0 (0%) | |
Pure signet ring cell | 0 (0%) | 0 (0%) | |
Tumor differentiation | Well differentiated | 18 (69.2%) | 4 (22.2%) |
Moderately differentiated | 7 (26.9%) | 7 (38.9%) | |
Poorly differentiated | 1 (3.8%) | 7 (38.9%) | |
Lymphovascular invasion | 0 (0%) | 4 (22.2%) | |
Large vessel invasion | 0 (0%) | 1 (5.5%) | |
Perineural invasion | 0 (0%) | 1 (5.5%) | |
Tumor budding | Low | 0 (0%) | 1 (5.5%) |
Intermediate or high | 0 (0%) | 7 (38.9%) | |
Peritumoral inflammatory response | Lymphoplasmacytic inflammation with lymphoid aggregates | 6 (23%) | 7 (38.9%) |
Neutrophilic inflammation | 0 (0%) | 2 (11.1%) | |
Desmoplasia | 0 (0%) | 8 (44.4%) | |
Depth of invasion | m1 = 0 (0%) m2 = 7 (26.9%) m3 = 16 (61.5%) m4 = 3 (11.5%) | sm1 = 12 (66.7%) sm2 = 3 (16.7%) >sm2 = 3 (16.7%) | |