Table 6 Tumor budding and outcomes (n = 8)
Risk stratification based on morphology | Tumor budding score | Outcome |
|---|---|---|
High-risk features Poorly differentiated Perineural invasion DOI: sm3 | 1 | Esophagectomy with residual tumor, pT1bN0 |
High-risk features Poorly differentiated LVI present DOI: sm1 | 3 | Esophagectomy with residual tumor, pT1aN1 |
High-risk features Poorly differentiated DOI: sm1 | 2 | Liver metastases |
High-risk features DOI: sm2 R1 resection, deep and peripheral margin positive | 3 | Esophagectomy with residual tumor, pT1bN0 |
Low-risk morphology R1 resection, deep and peripheral margin positive | 3 | Esophagectomy with residual tumor, pT2N0 |
High-risk features* Poorly differentiated morphology Large-vessel invasion | 2 | Known case of esophageal adenocarcinoma, not surgical candidate, prior history of neoadjuvant chemotherapy, ESD performed for debulking |
High-risk features* Poorly differentiated adenocarcinoma LVI present | 2 | Known case of esophageal adenocarcinoma, not surgical candidate, prior history of neoadjuvant chemotherapy, ESD performed for debulking |
High-risk features Poorly differentiated adenocarcinoma Deep margin negative Peripheral margin positive | 3 | Esophagectomy: residual adenocarcinoma pT2N0 |