SOX11 is a sensitive and specific marker for pulmonary high-grade neuroendocrine tumors

Diagnostic Pathology

Table 4 Immunoreactivity for Neuroendocrine Markers in LCNEC ^update

Markers	No. of Cases	Positive markers	% of Cases
All negative	0		0
1 positive	5	1: SYN+	13
1 positive	5	4: CD56+
2 positive	10	2: SOX11+, INSM1+	26
		2: CD56+, SYN+
		3: SOX11+, CD56+
		3: SYN+, CGA+
3 positive	6	1: SOX11+, SYN+, CGA+	16
		1: CD56+, SYN+, INSM1+
		4: CD56+, SYN+, CGA+
4 positive	8	1: SOX11+, CD56+, SYN+, INSM1+	21
4 positive	8	7: CD56+, SYN+, CGA+, INSM1+
All positive	9		24
Total no.	38^a

Abbreviations: LCNEC, large cell neuroendocrine carcinoma; SYN, synaptophysin; INSM1, Insulinoma-associated protein 1; CGA, chromogranin A
^aTwenty-five cases were excluded from the 63 cases of LCNEC^update because immunohistochemical staining was not performed for all markers
Note: LCNEC^update refer to the updated categorization when SOX11+ large cell carcinoma with neuroendocrine morphology was regrouped into LCNEC

ISSN: 1746-1596