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Fig. 4 | Diagnostic Pathology

Fig. 4

From: ARID1A deficient undifferentiated spindle cell and rhabdoid sarcoma of the prostate: report of a unique case with emphasis on diagnostic implications

Fig. 4

Immunohistochemical and molecular genetic analyses of ARID1A deficient undifferentiated spindle cell and rhabdoid sarcoma of the prostate. The tumor cells are diffusely positive for (a) TLE-1 and focally positive for (b) AE1/3 and (c) CD34, and are negative for (d) claudin-4. Fluorescence in-situ hybridization analyses revealing negative for rearrangements of both the (e) SYT/SS18 and (f) BCOR loci (Insets in e and f indicating schematic diagram of break-apart probes flanking SYT/SS18 and BCOR, respectively). (g, h) ARID1A immunohistochemistry exhibiting that tumor cells show complete loss of nuclear ARID1A expression with retained strong reactivity in the native prostatic glands and background stromal cells (as indicated by arrows)

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Diagnostic Pathology

ISSN: 1746-1596

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