Table 2 Pooled analysis of sensitivity and specificity of included studies with 95% confidence interval
Study ID | Sensitivity | Specificity | Positive LR | Negative LR | DOR |
|---|---|---|---|---|---|
Agullo et al. | 0.576 (0.487–0.661) | 0.998 (0.989-1.000) | 299.39 (42.023–2133.1) | 0.425 (0.348–0.519) | 704.36 (96.091–5163) |
Agullo et al. | 0.447 (0.360–0.536) | 1.000 (0.993-1.000) | 472.42 (29.398–7591.7) | 0.553 (0.475–0.645) | 854.05 (52.241-13962.1) |
Agullo et al. | 0.231 (0.160–0.317) | 1.000 (0.992-1.000) | 228.93 (14.076–3723.5) | 0.767 (0.696–0.846) | 298.41 (18.060-4930.7) |
Agullo et al. | 0.496 (0.404–0.588) | 1.000 (0.992-1.000) | 485.98 (30.265–7803.7) | 0.505 (0.423–0.602) | 963.08 (58.809-15771.9) |
Abdelrazik et al. | 0.431 (0.359–0.505) | 1.000 (0.989-1.000) | 286.33 (17.860-4590.3) | 0.570 (0.503–0.645) | 502.65 (30.910-8173.8) |
Albert et al. | 0.796 (0.665–0.894) | 1.000 (0.990-1.000) | 567.87 (35.470-9091.7) | 0.209 (0.125–0.350) | 2712.1 (157.06-46833.5) |
Ciotti et al. | 0.308 (0.170–0.476) | 1.000 (0.715-1.000) | 7.500 (0.478–117.57) | 0.717 (0.564–0.912) | 10.455 (0.570-191.78) |
Kohmer et al. | 0.290 (0.204–0.389) | 0.250 (0.169–0.347) | 0.387 (0.279–0.536) | 2.840 (1.978–4.078) | 0.136 (0.073–0.255) |
Kohmer et al. | 0.320 (0.230–0.421) | 0.260 (0.177–0.357) | 0.432(0.318–0.589) | 2.615 (1.830–3.737) | 0.165 (0.090–0.305) |
Kohmer et al. | 0.180 (0.110–0.269) | 0.260 (0.177–0.357) | 0.243 (0.158–0.375) | 3.154 (2.238–4.445) | 0.077 (0.039–0.152) |
Kohmer et al. | 0.370 (0.276–0.472) | 0.260 (0.177–0.357) | 0.500 (0.378–0.662) | 2.423 (1.685–3.484) | 0.206 (0.113–0.377) |
Linares et al. | 0.157 (0.114–0.207) | 0.922 (0.881–0.951) | 2.000 (1.203–3.324) | 0.915 (0.858–0.975) | 2.186 (1.239–3.857) |
Nalumansia et al. | 0.700 (0.594–0.792) | 0.924 (0.874–0.959) | 9.262 (5.398–15.891) | 0.325 (0.236–0.446) | 28.538 (13.848–58.814) |
Pilarowski et al. | 0.023 (0.008–0.053) | 0.960 (0.925–0.982) | 0.576 (0.196–1.691) | 1.018 (0.984–1.052) | 0.566 (0.187–1.717) |
Pilarowski et al. | 0.556 (0.212–0.863) | 0.503 (0.462–0.545) | 1.119 (0.620–2.018) | 0.883 (0.423–1.841) | 1.267 (0.337–4.767) |
Salvagno et al. | 0.340 (0.288–0.394) | 0.994 (0.978–0.999) | 54.500 (13.575–218.81) | 0.665 (0.614–0.719) | 82.007 (20.035–335.66) |
Schildgen et al. | 0.329 (0.223–0.449) | 0.877 (0.779–0.942) | 2.667 (1.332–5.338) | 0.766 (0.638–0.919) | 3.483 (1.486–8.162) |
Schildgen et al. | 0.500 (0.381–0.619) | 0.781 (0.669–0.869) | 2.281 (1.399–3.721) | 0.640 (0.495–0.829) | 3.563 (1.738–7.302) |
Schildgen et al. | 0.877 (0.779–0.942) | 0.795 (0.684–0.880) | 4.267 (2.696–6.753) | 0.155 (0.083–0.289) | 27.496 (11.184–67.599) |
Scohy et al. | 0.387 (0.291–0.472) | 1.000 (0.916-1.000) | 32.608 (2.053–517.87) | 0.628 (0.544–0.725) | 51.913 (3.118–864.30) |
Toptan et al. | 0.500 (0.319–0.681) | 1.000 (0.907-1.000) | 39.000 (2.432–625.53) | 0.506 (0.359–0.714) | 77.000 (4.357–1360.8) |
Torres et al. | 0.060 (0.043–0.081) | 1.000 (0.994-1.000) | 77.000 (4.741–1250.6) | 0.940 (0.922–0.959) | 81.905 (5.021–1336.2) |
CK Mak et al. | 0.343 (0.191–0.522) | 1.000 (0.900-1.000) | 25.000 (1.538–406.50) | 0.662 (0.520–0.843) | 37.766 (2.132–668.99) |
CK Mak et al. | 0.457 (0.288–0.634) | 1.000 (0.900-1.000) | 33.000 (2.057–529.44) | 0.549 (0.406–0.744) | 60.077 (3.416–1056.6) |
CK Mak et al. | 0.111 (0.037–0.241) | 1.000 (0.921-1.000) | 11.000 (0.626–193.25) | 0.890 (0.797–0.994) | 12.358 (0.663–230.48) |
CK Mak et al. | 0.400 (0.257–0.557) | 1.000 (0.921-1.000) | 37.000 (2.297–595.89) | 0.604 (0.476–0.768) | 61.218 (3.546–1056.9) |
Prince-Guerra et al. | 0.525 (0.467–0.583) | 0.999 (0.997-1.000) | 409.57 (152.91–1097.0) | 0.476 (0.422–0.536) | 861.29 (314.78-2356.6) |
Courtellemont et al. | 0.967 (0.918–0.991) | 1.000 (0.971-1.000) | 246.56 (15.502–3921.4) | 0.037 (0.015–0.092) | 6658.3 (354.65-125004.7) |
Courtellemont et al. | 0.706 (0.525–0.849) | 1.000 (0.897-1.000) | 49.000 (3.100-774.56) | 0.304 (0.183–0.506) | 161.0 (9.002–2879.3) |
Pere et al. | 0.958 (0.857–0.995) | 0.981 (0.897-1.000) | 49.833 (7.147–347.45) | 0.042 (0.011–0.165) | 1173.0 (102.92-13368.3) |
Pere et al. | 0.917 (0.800-0.977) | 0.865 (0.742–0.944) | 6.810 (3.401–13.636) | 0.096 (0.037–0.248) | 70.714 (19.333–258.66) |
Pere et al. | 0.923 (0.749–0.991) | 1.000 (0.858-1.000) | 45.37 (2.910–707.30) | 0.094 (0.029–0.308) | 480.20 (21.093-10527.9) |
Pere et al. | 0.979 (0.889–0.999) | 0.981 (0.897-1.000) | 50.917 (7.306–354.84) | 0.021 (0.003–0.148) | 2397.0 (145.76–39,418) |
Pere et al. | 0.915 (0.796–0.976) | 0.846 (0.719–0.931) | 5.947 (3.125–11.316) | 0.101 (0.039–0.259) | 59.125 (16.576–210.89) |
Fabre et al. | 0.041 (0.017–0.083) | 0.959 (0.917–0.981) | 1.000 (0.359–2.789) | 1.000 (0.957–1.045) | 1.000 (0.343–2.916) |
Cerutti et al. | 0.706 (0.612–0.790) | 1.000 (0.983-1.000) | 312.82 (19.576–4998.8) | 0.296 (0.222–0.395) | 1056.4 (63.918-17459.1) |
Montesinosa et al. | 0.719 (0.632–0.795) | 1.000 (0.950-1.000) | 104.69 (6.597–1661.4) | 0.285 (0.216–0.375) | 367.47 (22.176–6089.1) |
Montesinosa et al. | 0.688 (0.600-0.766) | 0.958 (0.883–0.991) | 16.500 (5.417–50.263) | 0.326 (0.251–0.424) | 50.600 (15.016–170.51) |
Montesinosa et al. | 0.711 (0.624–0.788) | 1.000 (0.950-1.000) | 103.56 (6.525–1643.6) | 0.293 (0.223–0.384) | 353.80 (21.360-5860.2) |