Table 1 Report of ovarian endocrine cell micronests: cases published between 1999 – present (including our case)
Age/Sex | Ovarian tumor | Presenting symptom | Tumor size (cm) | Immunohistochemistry/Special stains | Follow-up (mo) | ||
|---|---|---|---|---|---|---|---|
Positive | Negative | ||||||
Ishikura et al., 1999 [7] | 59/F | Ovarian mucinous cystadenofibroma | Abdominal pain | 6 | Chromogranin and keratin (weak); Stains for argentaffin cells (Fontana-Masson) and argyrophil cells (Grimelius) | Neurophysin, gastrin, insulin, glucagon, somatostatin | NED, 12 mo |
Stewart et al., 2008 [8] | 61/F | Ovarian mucinous adenocarcinoma with mucinous borderline component | Tiredness, abdominal discomfort, bloating | 15 | CK7, chromogranin, synaptophysin, CD56 | CK20 | Adjuvant chemotherapy, NED, 16 mo |
Stewart et al., 2021 [10] | 31/F | Ovarian mucinous cystadenoma | Incidental finding at screening ultrasound for pregnancy | 16 | CK7 (focal, strong), chromogranin and synaptophysin (diffuse, strong), CDX2 and PAX8 (focal, moderate) | CK20, ER, MUC5AC, MUC6, inhibin, calretinin, SF1 | NR |
Current case | 27 F | Mucinous borderline tumor | Abdominal pain and fullness | 23 | CK, EMA, synaptophysin; Ki-67 proliferation index low (<1%) | Inhibin | NED, 10 mo |