Table 2 Histopathological features of subungual benign melanocytic proliferation and subungual melanoma in situ
Features | Subungual benign melanocytic proliferation (n = 14), n (%) | Subungual Melanoma in situ (n = 13), n (%) | p-value |
|---|---|---|---|
Melanocyte density | 0.182 | ||
≤ 30 cells/mm | 10 (71.4) | 6 (46.2) | |
> 30 cells/mm | 4 (28.6) | 7 (53.8) | |
Confluency | < 0.001* | ||
Yes | 5 (35.7) | 13 (100.0) | |
No | 9 (64.3) | 0 (0.0) | |
Pagetoid melanocytosis | 0.006* | ||
Yes | 6 (42.9) | 12 (92.3) | |
No | 8 (57.1) | 1 (7.7) | |
Inflammation | 0.883 | ||
Yes | 5 (35.7) | 5 (38.5) | |
No | 9 (64.3) | 8 (61.5) | |
Atypia | < 0.001* | ||
No | 6 (42.9) | 0 (0.0) | |
Mild | 6 (42.9) | 3 (23.1) | |
Moderate | 2 (14.3) | 5 (38.5) | |
Severe | 0 (0.0) | 5 (38.5) | |
Melanophage | 0.516 | ||
Yes | 8 (57.1) | 9 (69.2) | |
No | 6 (42.9) | 4 (30.8) | |
Melanin pigment | 1.000 | ||
Basilar | 4 (28.6) | 4 (30.8) | |
Entire | 10 (71.4) | 9 (69.2) | |
cyclin D1 | 1.000 | ||
Positive | 4 (28.6) | 3 (23.1) | |
Negative | 7 (71.4) | 9 (66.9) | |
PRAME | <0.001a | ||
Positive | 1 (7.1) | 10 (76.9) | |
Negative | 13 (92.9) | 3 (23.1) |