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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Diagnostic utility of CSF1 immunohistochemistry in tenosynovial giant cell tumor for differentiating from giant cell-rich tumors and tumor-like lesions of bone and soft tissue

Fig. 2

Pathological findings of MTSGCT and DTSGCT originated in the intervertebral joint of thoracic vertebra

a. MTSGCT consisted of diffuse proliferation of round to ovoid mononuclear tumor cells with coarse chromatin and conspicuous nucleoli. Mitotic figures were observed

b. The mononuclear tumor cells were negative for CSF1.

c. DTSGCT arose in the intervertebral joint of thoracic vertebra that consists of admixture of mononuclear cells, osteoclast-like giant cells, and inflammatory infiltrates with various degrees of collagenous stroma

d. CSF1-positive mononuclear tumor cells were scattered in the tumor. This case was initially diagnosed as giant cell reparative granuloma but finally determined to be DTSGCT involving the vertebra by CSF1 IHC.

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Diagnostic Pathology

ISSN: 1746-1596

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