Fig. 2

Spatial TILs phenotype and sTILs scores association with NACT response. A Spatial TILs phenotype and its association with response to NACT. Table showing the number of patients according to their TILs spatial phenotype and pathological response, where the response is measured as pCR and RD. Distribution of the number of patients across four phenotypes of spatial TILs was analyzed with the 4*2 χ2 contingency test using GraphPad Prism v.5. The bold font indicates significant p-values. B-E Spatial TILs phenotypes and its association with response to NACT across subtypes. Stacked bar graph representing percent number of patients with each spatial TILs phenotype with respect to NACT response. The therapy response is reported as pCR and RD according to the spatial TILs phenotype of the tumor for B. the IDC cohort, C. ER+ subtype D. HER2+ subtype E. TNBC subtype. The number of patients and percentage is shown in each bar as n (%). F Table showing the distribution of IDC and TNBC patients with pCR or RD with respect to binned sTILs score; Low sTILs (< 10%), Moderate sTILs (10–40%) and High sTILs (≥40%). χ2 p-value was computed using GraphPad Prism V.5. G-J; Box plots depicting mean sTILs scores separated according to the response to NACT for the cohort and the three subtypes. The number of tissue samples (n) is shown on top of each bar. Error bars represent 10th and 90th percentile values. Mann Whitney test was performed to analyze significant distribution of mean sTILs scores. p-value < 0.05 is represented with ‘*’, < 0.01 with ‘**’ and, < 0.0001 with ‘***’. ns = non-significant. GraphPad Prism v.5 was used for the graphs and statistical calculations