Fig. 4

Disease-free survival (DFS) for five-year follow-up according to the spatial TILs phenotype and sTILs scores. Disease-free survival (DFS) was calculated as number of months from the date of surgery till the recurrence diagnosis date or last follow-up date up to five years. Kaplan-Meier survival plots for disease-free survival (DFS) are plotted. Each drop shown as a vertical line represents an event i.e., local, or distant recurrence. Survival probability with respect to the spatial TILs phenotype is analyzed using IBM SPSS Statistics v. 21.0.0.0. The number of patients at risk at each time interval of 10 months from 0 to 60 months is shown. The number of events is indicated in brackets at respective time points. A-D DFS for the four phenotypes of the spatial TILs; Intra-tumoral TILs, Peri-tumoral TILs, Stromal TILs, and Desert TILs for A; the IDC cohort, B; ER+ subtype C; HER2+ subtype and D; TNBC subtype. In the graph, X-axis represents the time scale in months, and Y-axis represents the survival probability. The green line indicates patients with stromal TILs, the blue line indicates patients with peri-tumoral TILs, the purple line indicates patients with intra-tumoral TILs, and the red line indicates patients with desert TILs phenotype. E-H DFS with respect to binned percent stromal TILs infiltration score. Kaplan-Meier survival plots for disease-free survival (DFS) according to low, moderate & high sTILs score bins for E; the IDC cohort, F; ER+ subtype, G; HER2+ subtype and H; TNBC. In the graph, X-axis represents the time scale in months, and Y-axis represents the survival probability. The blue line indicates patients with low sTILs scores, and the red line indicates patients with moderate scores & green indicates high sTILs scores