Table 2 Immunohistochemical staining patterns and mutational analysis of TP53
From: p53 immunostaining pattern is a useful surrogate marker for TP53 gene mutations
Mutation type | Immunohistochemical pattern of p53 | Total | ||
|---|---|---|---|---|
Overexpression | Null type | Usual | ||
SNV | 65 (75.6) | 0 (0) | 0 (0) | 65 |
Frameshift indel | 0 (0) | 7 (25) | 0 (0) | 7 |
In-frame indel | 4 (4.7) | 0 (0) | 0 (0) | 4 |
Truncation | 1 (1.2) | 9 (32.1) | 0 (0) | 10 |
Copy-number loss | 1 (1.2) | 0 (0) | 0 (0) | 1 |
Splice | 2 (2.3) | 7 (25) | 0 (0) | 9 |
SNV/Frameshift indel | 1 (1.2) | 1 (3.6) | 0 (0) | 2 |
SNV/SNV | 5 (5.8) | 0 (0) | 0 (0) | 5 |
Splice/Truncation | 0 (0) | 1 (3.6) | 0 (0) | 1 |
Wild type | 7 (8.1) | 3 (10.7) | 21 (100) | 31 |
Total | 86 | 28 | 21 | 135 |