Table 3 Immunohistochemical staining patterns and predicted functional consequence of TP53 mutations
From: p53 immunostaining pattern is a useful surrogate marker for TP53 gene mutations
Functional consequence | Immunohistochemical pattern of p53 | ||
|---|---|---|---|
Overexpression | Null type | Usual | |
IF-DBD | 75 (87.2) | 0 (0) | 0 (0) |
DISRUPTED | 4 (4.7) | 25 (89.3) | 0 (0) |
Wild type | 7 (8.1) | 3 (10.7) | 21 (100) |
Total | 86 | 28 | 21 |