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Table 3 Mean Tils values according to different clinicopatologic factors  in primaries and in recurrences

From: Quantities of CD3+, CD8+ and CD56+ lymphocytes decline in breast cancer recurrences while CD4+ remain similar

 

H&E primary

p-value

H&E recurrence

p-value

CD3 primary

p-value

CD3 recurrence

p-value

CD8 primary

p-value

CD8 recurrence

p-value

CD4 primary

p-value

CD4 recurrence

p-value

SRI

8.69

0.036*

3.62

0.463

13.03

0.081

9.04

0.865

13.89

0.619

9.78

0.346

3.46

0.01*

1.87

0.425

IRI

7.69

 

3.89

 

14.52

 

6.97

 

12.73

 

8.13

 

1.75

 

1.59

 

LRI

4.35

 

2.12

 

8.85

 

5.9

 

10.56

 

7.19

 

1.4

 

2.08

 

Ki67 ≤20%

7.40

0.298

3.12

0.671

11.50

0.104

7.09

0.423

12.01

0.164

8.22

0.964

1.91

0.024*

1.61

0.647

Ki67 >20%

6.38

 

3.38

 

15.00

 

6.47

 

13.87

 

7.13

 

2.42

 

1.68

 

G1

6.07

0.001*

4.73

0.062

5.23

<0.001*

10.5

0.063

7.5

0.003*

11.79

0.068

1.56

0.585

3.06

0.225

G2

5.14

 

3.26

 

10.31

 

5.35

 

11.09

 

7.17

 

2.09

 

1.65

 

G3

12.12

 

2.66

 

19.19

 

9.81

 

18.19

 

9.63

 

2.7

 

1.58

 

Ductal

9.02

0.138

2.6

0.410

15.63

0.002*

7.11

0.793

14.36

0.126

7.97

0.917

2.61

0.422

1.37

0.118

Lobular

4.67

 

4.2

 

7.88

 

7.56

 

10.41

 

9.1

 

1.69

 

2.45

 

ER negative

9.5

0.542

2.38

0.101

16.22

0.01*

5.94

0.089

14.27

0.787

6.2

0.046*

2.55

0.975

0.91

0.01*

ER positive

5.76

 

3.73

 

9.4

 

8.07

 

11.33

 

9.61

 

1.83

 

2.24

 

PR negative

9.11

0.502

2.47

0.153

16.47

0.034*

6.13

0.095

14.79

0.293

6.73

0.281

2.94

0.811

0.95

0.063

PR positive

6.27

 

3.58

 

10

 

7.83

 

11.41

 

9.03

 

1.71

 

2.12

 

HER2 negative

6.66

0.379

3.32

0.094

10.77

0.022*

7.3

0.779

11.31

0.034*

8.07

0.286

1.78

0.202

1.86

0.229

HER2 positive

9.94

 

2.46

 

21.64

 

7.0

 

19.07

 

9.85

 

3.76

 

0.87

 

Size of primary <20 mm

7.42

0.140

  

12.2

0.13

  

12.61

0.362

  

1.98

0.100

  

Size of primary ≥20 mm

6.86

   

12.14

   

12.67

   

2.35

   
  1. Mean % of different subtypes of Tils in primaries and recurrences according to recurrence groups and clinicopathologic factors and the p-values for the significance of the differences within factors. H&E Tils percentages in hematoxylin and eosin-stained sections, SRI Short recurrence interval <2 y, IRI Intermediate recurrence interval 5-10 y, LRI Long recurrence interval >10 y. HER2 Human epidermal growth factor receptor 2, ER Estrogen receptor, PR Progesterone receptor, G Grade. Statistically significant differences within different clinicopathologic factors are marked with *
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Diagnostic Pathology

ISSN: 1746-1596

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