Table 3 In silico predicting results for the two variants
POLE p.T278K | POLE p.T278M | |
|---|---|---|
POLE -score | 4 | 3 |
Mutation taster | Disease causing | Disease causing |
PolyPhen-2 | Probably damaging (score = 1.000) | Probably damaging (score = 1.000) |
PROVEAN | Deleterious (score=-5.29) | Deleterious (score=-5.23) |
PANTHER | Probably damaging | Probably damaging |
SNAP2 | Effect | Effect |
SIFT | Damaging (score = 0.001) | Damaging (score = 0.001) |