Variables | Univariate analysis | P-value† | |
---|---|---|---|
β | HR (95% CI) | ||
Age (years) | −0.011 | 0.989 (0.968–1.010) | 0.306 |
Male gender | 0.618 | 1.855 (1.051–3.272) | 0.033 |
Liver disease etiology | |||
Smoking | 0.573 | 1.774 (1.121–2.807) | 0.014 |
Drinking | 0.900 | 2.461 (1.535–3.944) | < 0.001 |
Decompensation | 0.998 | 2.713 (1.429–5.152) | 0.002 |
Ascites | 0.897 | 2.452 (1.440–4.176) | 0.001 |
Hepatic encephalopathy | 0.327 | 1.387 (0.506–3.800) | 0.525 |
Bacterial infection | −0.100 | 0.905 (0.497–1.648) | 0.744 |
Location of varices at index gastroscopy | |||
Gastric varices only | Reference | ||
Esophageal varices only | −0.714 | 0.489 (0.067–3.602) | 0.483 |
Esophageal and gastric | 0.910 | 2.485 (1.542–4.004) | < 0.001 |
Size of varices | |||
Small | Reference | ||
Medium | 1.152 | 3.165 (1.629–6.151) | 0.001 |
Large | 1.699 | 5.469 (2.950–10.139) | < 0.001 |
Red wale marks | 1.469 | 4.346 (2.691–7.017) | < 0.001 |
Laboratory data | |||
ALT (U/L) | −0.004 | 0.996 (0.992–1.000) | 0.005 |
AST (U/L) | −0.003 | 0.997 (0.993–1.001) | 0.093 |
TBIL (μmol/L) | −0.002 | 0.998 (0.994–1.003) | 0.487 |
GGT (U/L) | 0.001 | 1.001 (1.000–1.002) | 0.006 |
ALP (U/L) | −0.001 | 0.999 (0.995–1.002) | 0.548 |
ALB (g/L) | −0.034 | 0.967 (0.929–1.005) | 0.091 |
WBC (× 10 9 /L) | 0.004 | 1.004 (0.897–1.125) | 0.938 |
RBC (× 10 12 /L) | −0.425 | 0.654 (0.477–0.898) | 0.009 |
PLT (× 10 9 /L) | −0.002 | 0.998 (0.992–1.003) | 0.414 |
NLR | 0.082 | 1.086 (1.018–1.158) | 0.013 |
HCT (%) | −0.053 | 0.948 (0.919–0.978) | 0.001 |
K (mmol/L) | −0.284 | 0.752 (0.441–1.283) | 0.296 |
NA (mmol/L) | −0.006 | 0.994 (0.936–1.056) | 0.848 |
BUN (mmol/L) | −0.072 | 0.930 (0.824–1.050) | 0.243 |
CREA (μmol/L) | −0.005 | 0.995 (0.983–1.007) | 0.381 |
GLU (mmol/L) | −0.091 | 0.913 (0.814–1.024) | 0.119 |
PT (s) | 0.014 | 1.014 (0.939–1.095) | 0.721 |
PTA (%) | −0.009 | 0.991 (0.977–1.004) | 0.172 |
Spleen thickness (mm) | 0.046 | 1.048 (1.027–1.068) | < 0.001 |
Portal vein diameter (mm) | 0.113 | 1.120 (0.987–1.270) | 0.079 |
Child-Pugh grade‡ | |||
A | Reference | ||
B | −0.190 | 0.827 (0.500–1.369) | 0.827 |
C | −0.085 | 0.919 (0.467–1.807) | 0.919 |
MELD a | −0.018 | 0.982 (0.935–1.032) | 0.481 |