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Table 1 Factors associated with prediction of EGVB

From: Machine learning-based model for predicting the esophagogastric variceal bleeding risk in liver cirrhosis patients

Variables

Univariate analysis

P-value

β

HR (95% CI)

Age (years)

−0.011

0.989 (0.968–1.010)

0.306

Male gender

0.618

1.855 (1.051–3.272)

0.033

Liver disease etiology

Smoking

0.573

1.774 (1.121–2.807)

0.014

Drinking

0.900

2.461 (1.535–3.944)

<  0.001

Decompensation

0.998

2.713 (1.429–5.152)

0.002

Ascites

0.897

2.452 (1.440–4.176)

0.001

Hepatic encephalopathy

0.327

1.387 (0.506–3.800)

0.525

Bacterial infection

−0.100

0.905 (0.497–1.648)

0.744

Location of varices at index gastroscopy

Gastric varices only

Reference

  

Esophageal varices only

−0.714

0.489 (0.067–3.602)

0.483

Esophageal and gastric

0.910

2.485 (1.542–4.004)

<  0.001

Size of varices

Small

Reference

  

Medium

1.152

3.165 (1.629–6.151)

0.001

Large

1.699

5.469 (2.950–10.139)

<  0.001

Red wale marks

1.469

4.346 (2.691–7.017)

<  0.001

Laboratory data

ALT (U/L)

−0.004

0.996 (0.992–1.000)

0.005

AST (U/L)

−0.003

0.997 (0.993–1.001)

0.093

TBIL (μmol/L)

−0.002

0.998 (0.994–1.003)

0.487

GGT (U/L)

0.001

1.001 (1.000–1.002)

0.006

ALP (U/L)

−0.001

0.999 (0.995–1.002)

0.548

ALB (g/L)

−0.034

0.967 (0.929–1.005)

0.091

WBC (×  10 9 /L)

0.004

1.004 (0.897–1.125)

0.938

RBC (×  10 12 /L)

−0.425

0.654 (0.477–0.898)

0.009

PLT (× 10 9 /L)

−0.002

0.998 (0.992–1.003)

0.414

NLR

0.082

1.086 (1.018–1.158)

0.013

HCT (%)

−0.053

0.948 (0.919–0.978)

0.001

K (mmol/L)

−0.284

0.752 (0.441–1.283)

0.296

NA (mmol/L)

−0.006

0.994 (0.936–1.056)

0.848

BUN (mmol/L)

−0.072

0.930 (0.824–1.050)

0.243

CREA (μmol/L)

−0.005

0.995 (0.983–1.007)

0.381

GLU (mmol/L)

−0.091

0.913 (0.814–1.024)

0.119

PT (s)

0.014

1.014 (0.939–1.095)

0.721

PTA (%)

−0.009

0.991 (0.977–1.004)

0.172

Spleen thickness (mm)

0.046

1.048 (1.027–1.068)

<  0.001

Portal vein diameter (mm)

0.113

1.120 (0.987–1.270)

0.079

Child-Pugh grade‡

A

Reference

  

B

−0.190

0.827 (0.500–1.369)

0.827

C

−0.085

0.919 (0.467–1.807)

0.919

MELD a

−0.018

0.982 (0.935–1.032)

0.481

  1. Comparison results between the derivation and validation cohorts
  2. aChild–Pugh grade and MELD score were not included in the least absolute shrinkage and selection operator regression analyses
  3. Abbreviations: ALB Albumin; ALP Alkaline phosphatase, ALT Alanine aminotransferase, AST Aspartate aminotransferase, BUN Blood urine nitrogen, CI Confidence interval, CREA Creatinine, EGVB Esophagogastric variceal bleeding; GGT γ-glutamyl transferase, GLU Glucose, HBV Hepatitis B virus, HCT hEmatocrit, HCV Hepatitis C virus, HR Hazard ratio, K Potassium, MELD Model for end-stage liver disease, NA Sodium, NLR Neutrophil-lymphocyte ratio, PLT Platelet, PT Prothrombin time, PTA Prothrombin time activity, RBC Red blood cell, TBIL Total bilirubin, WBC White blood cell