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Fig. 2 | Diagnostic Pathology

Fig. 2

From: Clear cell stromal tumor of the lung with multinucleated giant cells: a report of a case with YAP1-TFE3 fusion

Fig. 2

Breakpoit analysis of the YAP1-TFE3 fusion RNA sequencing analysis revealed 265 bases long sequence (identified in 242 × reads; a copy of the fusion sequence is provided in the lower part of the figure). Verified breakpoints are indicated by double line and correspond to YAP1 breakpoint (GRCh37) chr11:102,056,862 and TFE3 breakpoint (GRCh37) chrX:48,891,297. According to the main RefSeq reference sequence NM_006106, the final fusion transcript includes exonisation of a part of YAP1 intron 3, which corresponds to YAP1 exon 4 according to other alternative transcripts (e.g. NM_001130145), followed by exon 7 of TFE3 (NM_006521). The upper part of the figure shows a diagram of the sequence identification

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Diagnostic Pathology

ISSN: 1746-1596

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