Fig. 5

Representative images of typical reactive lymphocytes in the peripheral blood smear in acute EBV infection. Type 2 Downey cells – large, atypical lymphocytes with moderate to abundant scalloped cytoplasm – are the most common (A and B) with some showing pseudopod-like cytoplasmic extensions (B, arrowhead). Plasmacytoid lymphocytes (C) and those with clover-leaf nuclei (D) are less commonly encountered. (Note: images in this figure were taken from confirmed archival cases.)