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Fig. 1 | Diagnostic Pathology

Fig. 1

From: CIN grades possessing different HPV RNA location patterns and RNAscope is helpful tool for distinguishing squamous intraepithelial lesions in difficult cervical cases

Fig. 1

The Location Character of HPV RNA in different CIN grades in the control group. Row1 (a-d): HR-HPV RNA in CIN1 lesion (P16 + and Ki67 +) show diffuse clustered expression pattern in nuclei/cytoplasmic, staining areas is mainly located on the surface epithelium (d). Row2 (e–h): HR-HPV RNA in CIN2 lesion (P16 + and Ki67 +) show nucleus/cytoplasmic dot positivity in the basal and parabasal layer, and combined with diffuse cluster nuclei positivity on the surface epithelium (h, arrow). Row3 (i-l) and Row4 (m-p): HR-HPV RNA in CIN3 lesion (P16 + and Ki67 +) show dotted full-thickness nucleus/cytoplasmic scattered staining(l, arrow) or combined with a clustered nuclei staining on the superficial cells (bottom right of image p). Row5 (q-t): The expression pattern of LR-HPV RNA in CIN1 lesion (P16 + and Ki67 +) was like HR-HPV, showing diffuse clustered expression pattern in nuclei/cytoplasmic, staining areas is mainly located on the surface epithelium (t, arrow)

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Diagnostic Pathology

ISSN: 1746-1596

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