Skip to main content

Table 2 Overview of overall positivity (%) of 26 markers and differences between tumor types

From: A comprehensive immunohistochemical analysis of 26 markers in 250 cases of serous ovarian tumors

Marker

HGSC (n = 114)

LGSC (n = 97)

mSBT (n = 39)

HGSC vs. (LGSC + mSBT) p-value

HGSC vs. LGSC p-value

LGSC vs. mSBT p-value

ER

   

< 0.001

 < 0.001

0.998

n

114

94

39

   

range (mean/median)

0–100 (72/90)

0–100 (91.1/98)

68–100 (95/98)

   

PR

   

 < 0.001

0.004

0.003

n

114

97

39

   

range (mean/median)

0–100 (8.7/0)

0–100 (19.1/5)

0–90 (29.8/20)

   

PAX8

   

< 0.001

< 0.001

0.408

n

114

96

39

   

range (mean/median)

0–100 (96.5/100)

2–100 (81.5/90)

45–100 (86.2/92)

   

ARID1A

   

 < 0.001

< 0.001

0.752

n

114

95

38

   

range (mean/median)

0–100 (88.5/97.5)

0–100 (57.8/60)

1–100 (57.6/65)

   

PTEN

   

< 0.001

< 0.001

0.953

n

114

96

38

   

range (mean/median)

0–100 (54.1/62.5)

0–100 (76.9/85)

20–100 (78.1/83.5)

   

HNF1B

   

0.878

0.800

0.304

n

114

93

34

   

range (mean/median)

0–98 (14.2/0)

0–100 (15.4/0)

0–100 (21.5/0)

   

Napsin A

   

NULL

NULL

NULL

n

114

96

39

   

range (mean/median)

0

0

0

   

CDX2

   

0.706

0.757

0.927

n

114

97

39

   

range (mean/median)

0–95 (1.7/0)

0–10 (0.1/0)

0

   

NTRK

   

0.906

0.914

NULL

n

114

96

39

   

range (mean/median)

0–21 (0.2/0)

0

0

   

MUC4

   

0.463

0.525

0.927

n

114

97

39

   

range (mean/median)

0–30 (0.6/0)

0–7 (0.1/0)

0

   

BRG1

   

< 0.001

< 0.001

0.893

n

114

97

39

   

range (mean/median)

21–100 (89.9/95)

0–100 (99/100)

95–100 (99.9/100)

   

PAX2

   

< 0.001

< 0.001

0.171

n

114

95

37

   

range (mean/median)

0–98 (15.8/0)

0–100 (41.5/22)

0–100 (51.8/64)

   

Mammaglobin

   

0.002

0.001

0.034

n

114

96

37

   

range (mean/median)

0–95 (4.7/0)

0–75 (0.9/0)

0–22 (1.1/0)

   

SATB2

   

0.318

0.424

0.780

n

114

97

39

   

range (mean/median)

0–31 (0.9/0)

0–40 (0.5/0)

0

   

RB1

   

0.002

0.007

0.994

n

113

92

39

   

range (mean/median)

0–100 (68.6/90)

0–100 (64.1/74)

20–97 (67.4/67)

   

AMACR

   

0.993

0.822

0.544

n

114

96

39

   

range (mean/median)

0–75 (2.4/0)

0–80 (2.6/0)

0–5 (0.3/0)

   

TTF1

   

0.905

0.914

NULL

n

114

97

39

   

range (mean/median)

0–5 (0.1/0)

0

0

   

Cyclin E1

   

< 0.001

< 0.001

0.592

n

114

93

37

   

range (mean/median)

0–100 (67.2/79)

0–90 (23.9/17)

0–75 (21.2/15)

   

Statmin

   

< 0.001

 < 0.001

0.404

n

114

94

38

   

range (mean/median)

0–100 (70.2/80)

0–98 (23.9/12)

1–70 (15.4/8.5)

   

BCOR

   

0.278

0.273

0.817

n

114

97

39

   

range (mean/median)

0–4 (0.2/0)

0

0–4 (0.1/0)

   

L1CAM

   

0.046

0.134

0.484

n

114

95

37

   

range (mean/median)

0–100 (12.0/0)

0–90 (7.6/0)

0–60 (2.4/0)

   

LMP2

   

< 0.001

 < 0.001

0.264

n

114

95

38

   

range (mean/median)

0–100 (72.6/95)

45–100 (95.3/100)

60–100 (98.3/100)

   

CD44

   

< 0.001

< 0.001

0.753

n

114

93

37

   

range (mean/median)

0–100 (6.9/0)

0–12 (0.5/0)

0–6 (0.3/0)

   

Ki67

   

 < 0.001

< 0.001

0.948

n

114

91

37

   

range (mean/median)

0–95 (45.6/44)

0–29 (3.0/1)

0–5 (2.0/2)

   
  1. p-values are based on Mann–Whitney U test, NULL = values could not be generated, significant differences are indicated in bold font
  2. HGSC High grade serous carcinoma, LGSC Low grade serous carcinoma, mSBT Micropapillary serous borderline tumor, NULL values could not be generated