Table 1 Cases of previously reported low-grade papillary Schneiderian carcinoma
No | Age | Sex | Initial symptoms | Original diagnosis | Involved site | Local recurrence | Nodal metastasis | Distant metastasis | Adjunctive treatment | Follow-up | p53 | Ki67 | HPV | EGFR, KRAS | DEK-AFF2 | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 47 | F | Nasal obstruction, polyps | Fungiform Schneiderian papilloma | ES, NC, MS, FS, cheek, OB |  > 10 times (18 years) | Yes | No | CT, RT | 18 years, DOD | 50% | 5% | - | WT | exon7-exon4 | |
2 | 42 | F | Nasal obstruction, rhinorrhea | Oncocytic papilloma | NC, MS, ES | Once (3Â years) | No | No | RT | 21Â months, NED | 50% | 10% | - | NA | NA | [2] |
3 | 65 | F | Nasal obstruction | Schneiderian papilloma | NC, MS, ME, ET | Once (1Â year) | No | No | RT | 3Â months, NED | NA | NA | NA | NA | NA | [3] |
4 | 56 | F | Nasal discharge, facial pain | Transitional proliferation with inverted growth | MS, ES, NC, PF, OB, IF | Once (1 year) | No | No | No |  > 12 months, NED | Positive |  < 10% | - | NA | NA | [4] |
5 | 68 | M | Nasal obstruction | Low-grade papillary Schneiderian carcinoma | NC | No | No | No | No | 16 months, NED | 50% | 2–50% | - | WT | NA | [5] |
6 | 53 | F | Nasal obstruction, loss of smell, headache | Sinonasal papilloma | NC, NP, ME, ET | Four times | No | No | RT | 48Â months, AWD | 20% | 5% | - | WT | NA | [6] |
7 | 64 | F | Nasal obstruction, epistaxis, loss of smell | Inverted papilloma | NC, FS, MS, ES, SS, IF, PF, ME, NP | Four times | No | No | No | 7Â months, DOD | 10% | 5% | - | WT | NA | [6] |
8 | 18 | F | Nasal obstruction, epistaxis | Papilloma | NC, ES, MS, ET, ME, NP | Nine times | Yes | lung | CT, RT | 13Â months, AWD | 20% | 5% | - | WT | NA | [6] |
9 | 53 | F | Nasal obstruction, epistaxis, epiphora tinnitus, aural fullness | Papilloma | NC, SS, SB, ET, ME, CS, NP | Twice | Yes | No | RT | 18Â months, AWD | 30% | 10% | - | WT | exon7-exon5 | |
10 | 51 | F | Nasal obstruction, purulent nasal discharge, epistaxis | Exophytic papilloma | NC | Twice | No | No | RT | 30Â months, NED | 10% | 5% | - | WT | exon7-exon5 | |
11 | NA | NA | (from No. 11 to 14) Neurological symptoms (sensory or auditory neuropathies), facial swelling, nasal obstruction and drainage | (from No. 11 to 14) Inverted papilloma, atypical squamous proliferation with papillary features, low-grade nonkeratinizing SCC, SCC in situ arising in an inverted papilloma | NC | No | No | No | CT, RT | NED | (from No. 11 to 14) average 43% (15–70%) | (from No. 11 to 14) average 27% (5–50%) | - | WT | NA | [7] |
12 | NA | NA | MS | No | No | No | CT, RT | NED | - | WT | NA | [7] | ||||
13 | NA | NA | Mastoid air cells, ME | No | No | No | No | NED | - | WT | NA | [7] | ||||
14 | NA | NA | NC | Once (10Â months) | No | No | No | 15Â months, AWD | - | WT | NA | [7] | ||||
15 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | - | WT |  +  | [8] |
16 | 64 | F | NA | LGPSC | NC, ES | NA | No | No | NA | NA | NA | NA | - | NA |  +  | [9] |
17 | 76 | F | Asymptomatic (detected by PET) | Inverted papilloma or LGPSC | NP | No | Yes | No | RT | 13Â months, DOA | NA | 15% | - | NA | NA | [10] |
18 | 69 | M | Nasal obstruction, cheek swelling, purulent rhinorrhea | LGPSC | MN, ES, NC, OB, Cheek | Not resectable | No | No | CT, RT | 8Â months, AWD | 100% | 90% | - | WT | - | This case |