Table 2 Distribution of tumour markers
From: “Evaluation of ROS1 expression and rearrangements in a large cohort of early-stage lung cancer”
Scoring group | Totally negative | Focal, weak | Focal, moderate/strong | Diffuse, weak | Diffuse, moderate/strong | No viable tumour cells |
|---|---|---|---|---|---|---|
D4D6 TMA N (%) | 837 (90.9) | 26 (2.8) | 1 (0.1) | 19 (2.1) | 8 (0.9) | 30 (3.3) |
Mean/median H-score (range) | 0 | 18.7/20 (5–40) | 35/35 (35) | 82.6/80 (60–130) | 221.3/220 (160–300) | |
FISH positiv | 2/68 | 0/5 | 0/1 | 0/19 | 3/7 | 0/1 |
NGS | 69/837 | 7/26 | 1/1 | 18/19 | 8/8 | 1/30 |
–RNA/ Fusions | ALK: 1 FGFR3: 1 MYB: 1 RET: 1 Failed: 2 Negative: 63 | Negative: 6 Failed: 1 | Negative: 1 | Met exon 14 skipping: 1 Failed: 1 Negative: 16 | ROS1: 3 Negative: 5 | Negative: 1 |
SP384 TMA N (%) | 827 (89.8) | 35 (3.8) | 1 (0.1) | 24 (2.6) | 15 (1.6) | 19 (2.1) |
Mean/median H-score (range) | 0 | 25.3/30 (5–40) | 40/40 (40) | 100.4/100 (60–140) | 204/200 (120–300) | |
FISH positive (Positive/total tested) | 2/56 | 0/7 | 0/1 | 0/21 | 3/15 | 0/1 |
NGS | 60/827 | 4/35 | 1/1 | 23/24 | 15/15 | 1/19 |
–RNA/Fusions | FGFR3: 1 MYB: 1 Failed: 2 Negative: 56 | RET: 1 Negative: 3 | Negative: 1 | ALK: 1 MET: 1 Failed:1 Negative: 20 | ROS1: 3 Failed: 1 Negative: 11 | Negative: 1 |