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Table 2 The frequency of mutations in selected genes in 100 primary ovarian clear cell carcinomas compared to the literature

From: A comprehensive molecular analysis of 113 primary ovarian clear cell carcinomas reveals common therapeutically significant aberrations

 

Primary OCCCs

Literature OCCCs

Gene

No. of cases

Mut/all

Mutation %

No. of cases

Mut/all

Mutation %

Range %

POLE

4/100

4

2/545

0

0–14

ARID1A*

51/100

51

678/1215

56

14-88

PIK3CA*

47/100

47

786/1825

43

13–67

KRAS

18/100

18

126/1169

11

0–43

TP53

12/100

12

208/1456

14

0–52

ATM

10/100

10

74/907

8

0–18

PPP2R1A

7/100

7

64/567

11

0–25

PTEN

6/100

6

47/866

5

0–17

  1. *several cases with two alterations in the respective gene. mut - class 4/5 mutation, e.g. likely pathogenic/pathogenic mutation(s) detected; list of referred literature is in Supplementary Table 21
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Diagnostic Pathology

ISSN: 1746-1596

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