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Table 1 Clinicopathological characteristics of the patients according to the different Her2 scores

From: Prevalence and clinicopathological associations of HER2 expression in non-small cell lung cancer: a retrospective study in Jordanian patients

Variables, n (%)

Total

Her2 score

Score 0

Score 1+

Score 2+

Score 3+

 

100 (100.0)

76 (76.0)

12 (12.0)

10 (10.0)

2 (2.0)

Age (Years)

     

≤ 60

23 (23.0)

14 (18.4)

4 (33.3)

5 (50.0)

0 (0.0)

> 60

77 (77.0)

62 (81.6)

8 (66.7)

5 (50.0)

2 (100.0)

Gender

     

Male

82 (82.0)

61 (80.3)

11 (91.7)

8 (80.0)

2 (100.0)

Female

18 (18.0)

15 (19.7)

1 (8.3)

2 (20.0)

0 (0.0)

Smoking history *

     

Never smoker

19 (19.4)

15 (20.3)

2 (16.7)

2 (20.0)

0 (0.0)

Former/ current smoker

79 (80.6)

59 (79.7)

10 (83.3)

8 (80.0)

2 (100.0)

Histological subtype

     

Adenocarcinoma

75 (75.0)

55 (72.4)

10 (83.3)

9 (90.0)

1(50.0)

Squamous cell carcinoma

24 (24.0)

20 (26.3)

2 (16.7)

1 (10.0)

1 (50.0)

Adenosquamous carcinoma

1 (1.0)

1 (1.3)

0 (0.0)

0 (0.0)

0 (0.0)

Differentiation

     

Low-grade (well and moderately differentiated)

38 (38.0)

31(40.8)

3 (25.0)

4 (40.0)

0 (0.0)

High-grade (poorly differentiated)

62 (62.0)

45 (59.2)

9 (75.0)

6 (60.0)

2 (100.0)

Tumor size

     

≤ 3

41 (41.0)

34 (44.7)

5 (41.7)

2 (20.0)

0 (0.0)

> 3

59 (59.0)

42 (55.3)

7 (58.3)

8 (80.0)

2 (100.0)

Lymph nodes metastasis

     

Positive

37 (37.0)

26 (34.2)

7 (58.3)

3 (30.0)

1 (50.0)

Negative

63 (63.0)

50 (65.8)

5 (41.7)

7 (70.0)

1 (50.0)

Pathological stage **

     

I

36 (37.1)

29 (39.2)

2 (18.2)

4 (40.0)

1(50.0)

II

33 (34.0)

24 (32.4)

5 (45.5)

3 (30.0)

1(50.0)

III

23 (23.7)

18 (24.3)

2 (18.2)

3 (30.0)

0 (0.0)

IV

5 (5.2)

3 (4.1)

2 (18.2)

0 (0.0)

0 (0.0)

Predominant histological pattern (For ADC cases, 75 cases)

     

Lepidic

18 (24.0)

12 (21.8)

2 (20.0)

4 (44.4)

0 (0.0)

Acinar

33 (44.0)

26 (47.3)

4 (40.0)

2 (22.2)

1 (100.0)

Papillary

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

Micropapillary

2 (2.7)

1 (1.8)

0 (0.0)

1 (11.1)

0 (0.0)

Solid

22 (29.3)

16 (29.1)

4 (40.0)

2 (22.2)

0 (0.0)

  1. * Indicates that two patients were excluded due to lack of smoking history, ** indicates that three patients were excluded as the specific stages were not determined. P-values of ≤ 0.05 were regarded as statistically significant. n = number
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Diagnostic Pathology

ISSN: 1746-1596

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