Table 2 Clinicopathological correlation with Her2 expression
Variables, n (%) | Total | Her2 Negative or equivocal (scores 0, 1+, and 2+) | Her2 Positive (score 3+) | P value |
|---|---|---|---|---|
| Â | 100 (100.0) | 98 (98.0) | 2 (2.0) | Â |
Age (Years) | Â | Â | Â | 1 |
≤ 60 | 23 (23.0) | 23 (23.5) | 0 (0.0) |  |
> 60 | 77 (77.0) | 75 (76.5) | 2 (100.0) |  |
Gender | Â | Â | Â | 1 |
Male | 82 (82.0) | 80 (81.6) | 2 (100.0) | Â |
Female | 18 (18.0) | 18 (18.4) | 0 (0.0) | Â |
Smoking history * | Â | Â | Â | 1 |
Never smoker | 19 (19.4) | 19 (19.8) | 0 (0.0) | Â |
Former/ current smoker | 79 (80.6) | 77 (80.2) | 2 (100.0) | Â |
Histological subtype | Â | Â | Â | 0.439 |
Adenocarcinoma | 75 (75.0) | 74 (75.5) | 1(50.0) | Â |
Squamous cell carcinoma | 24 (24.0) | 23 (23.5) | 1 (50.0) | Â |
Adenosquamous carcinoma | 1 (1.0) | 1 (1) | 0 (0.0) | Â |
Differentiation | Â | Â | Â | 0.524 |
Low-grade (well and moderately differentiated) | 38 (38.0) | 38 (38.8) | 0 (0.0) | Â |
High-grade (poorly differentiated) | 62 (62.0) | 60 (61.2) | 2 (100.0) | Â |
Tumor size | Â | Â | Â | 0.511 |
≤ 3 | 41 (41.0) | 41(41.8) | 0 (0.0) |  |
> 3 | 59 (59.0) | 57 (58.2) | 2 (100.0) |  |
Lymph nodes metastasis | Â | Â | Â | 1 |
Positive | 37 (37.0) | 36 (36.7) | 1 (50.0) | Â |
Negative | 63 (63.0) | 62 (63.3) | 1 (50.0) | Â |
Pathological stage ** | Â | Â | Â | 1 |
I | 36 (37.1) | 35 (36.8) | 1 (50.0) | Â |
II | 33 (34.0) | 32 (33.7) | 1 (50.0) | Â |
III | 23 (23.7) | 23 (24.2) | 0 (0.0) | Â |
IV | 5 (5.2) | 5 (5.3) | 0 (0.0) | Â |
Predominant histological pattern (For ADC cases, 75 cases) | Â | Â | Â | 1 |
Lepidic | 18 (24.0) | 18 (24.3) | 0 (0.0) | Â |
acinar | 33 (44.0) | 32 (43.2) | 1 (100.0) | Â |
Papillary | 0 (0.0) | 0 | 0 (0.0) | Â |
Micropapillary | 2 (2.7) | 2 (2.7) | 0 (0.0) | Â |
Solid | 22 (29.3) | 22 (29.7) | 0 (0.0) | Â |