Table 3 Clinicopathological correlation with Her2 expression (completely negative and any level of positivity)
Variables, n (%) | Total | Completely Negative Her2 (Score 0) | Any level of Her2 Positivity (3+, 2+, 1+) | P value |
|---|---|---|---|---|
| Â | 100 (100.0) | 76 (76) | 24 (24) | Â |
Age (Years) | Â | Â | Â | 0.092 |
≤ 60 | 23 (23.0) | 14 (18.4) | 9 (37.5) |  |
> 60 | 77 (77.0) | 62 (81.6) | 15 (62.5) |  |
Gender | Â | Â | Â | 0.550 |
Male | 82 (82.0) | 61 (80.3) | 21 (87.5) | Â |
Female | 18 (18.0) | 15 (19.7) | 3 (12.5) | Â |
Smoking history * | Â | Â | Â | 1 |
Never smoker | 19 (19.4) | 15 (20.3) | 4 (16.7) | Â |
Former/ current smoker | 79 (80.6) | 59 (79.7) | 20 (83.3) | Â |
Histological subtype | Â | Â | Â | 0.557 |
Adenocarcinoma | 75 (75.0) | 55 (72.4) | 20 (83.3) | Â |
Squamous cell carcinoma | 24 (24.0) | 20 (26.3) | 4 (16.7) | Â |
Adenosquamous carcinoma | 1 (1.0) | 1 (1.3) | 0 (0.0) | Â |
Differentiation | Â | Â | Â | 0.345 |
Low-grade (well and moderately differentiated) | 38 (38.0) | 31 (40.8) | 7 (29.2) | Â |
High-grade (poorly differentiated) | 62 (62.0) | 45 (59.2) | 17 (70.8) | Â |
Tumor size | Â | Â | Â | 0.235 |
≤ 3 | 41 (41.0) | 34 (44.7) | 7 (29.2) |  |
> 3 | 59 (59.0) | 42 (55.3) | 17 (70.8) |  |
Lymph nodes metastasis | Â | Â | Â | 0.338 |
Positive | 37 (37.0) | 26 (34.2) | 11 (45.8) | Â |
Negative | 63 (63.0) | 50 (65.8) | 13 (54.2) | Â |
Pathological stage ** | Â | Â | Â | 0.664 |
I | 36 (37.1) | 29 (39.2) | 7 (30.4) | Â |
II | 33 (34.0) | 24 (32.4) | 9 (39.1) | Â |
III | 23 (23.7) | 18 (24.3) | 5 (21.7) | Â |
IV | 5 (5.2) | 3 (4.1) | 2 (8.7) | Â |
Predominant histological pattern (For ADC cases, 75 cases) | Â | Â | Â | 0.585 |
Lepidic | 18 (24.0) | 12 (21.8) | 6 (30.0) | Â |
acinar | 33 (44.0) | 26 (47.3) | 7 (35.0) | Â |
Papillary | 0 (0.0) | 0 (0.0) | 0 (0.0) | Â |
Micropapillary | 2 (2.7) | 1 (1.8) | 1 (5.0) | Â |
Solid | 22 (29.3) | 16 (29.1) | 6 (30.0) | Â |