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Fig. 3 | Diagnostic Pathology

Fig. 3

From: A novel TPD52L2-ROS1 gene fusion expanding the molecular alterations in inflammatory myofibroblastic tumor: case report and literature review

Fig. 3

(A) Integrated Genomics Viewer snapshot showing paired-end sequencing data demonstrating a somatic intra-chromosomal TPD52L2-ROS1 rearrangement. The arrow points to the breakpoint of both genes. (B) The functional domains of the encoded TPD52L2 protein (2347 aa) and ROS1 protein (215 aa). The dotted lines indicate the breakpoints. Schematic representation of the novel TPD52L2-ROS1 chimeric protein (518 aa)

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Diagnostic Pathology

ISSN: 1746-1596

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