Table 1 Relationship between MCM4 expression and clinicopathological parameters in 124 upper tract urothelial carcinoma cases obtained by immunohistochemistry

Age

 ≤ 70 (n = 56)

29 (52%)

27

0.0410

 > 70 (n = 68)

48 (62%)

20

Sex

 Female (n = 30)

22 (73%)

8

0.1951

 Man (n = 94)

55 (59%)

39

Location

 Renal pelvis (n = 63)

32 (51%)

31

0.0309

 Ureter (n = 57)

42 (74%)

15

 Both (n = 4)

3 (75%)

1

Lateralization

 Right (n = 59)

37 (63%)

22

> 0.9999

 Left (n = 65)

40 (62%)

35

Morphology

 Papillary (n = 65)

36 (51%)

34

0.0086

 Nodular/Flat (n = 54)

41 (76%)

13

 Histological classification

 Pure UC (n = 97)

61 (63%)

36

0.3219

 Variants (n = 11)

9 (82%)

2

Histological grade

 Low grade (n = 55)

21 (38%)

34

< 0.0001

 High grade (n = 69)

56 (81%)

13

Pathological T stage

 pTa/is/1 (n = 61)

24 (39%)

37

< 0.0001

 pT2/3/4 (n = 63)

53 (84%)

10