Fig. 1

Pathology images and 18F-FDG PET/CT or MRI scans. Notes: Case 1A: 18F-FDG PET/CT image showed a FDG metabolism increasing mass with a maximum diameter of 6.35 cm (thick arrows) and a slightly enlarged lymph node (Size: 0.9*1.0 cm, SUVmax: 1.9) in the left pelvic cavity (thin arrow). Case 1B: T2 sagittal pelvic MRI showed a slight shrinking of the tumor (arrows) after treatment. Case 2A, B: T2 sagittal pelvic MRI scans reflected tumor volumes (arrows) before and after treatment were quantified and compared. Case 3A, B: A decreasing tumor volume assessed by T1 sagittal pelvic MRI (Case 3B) compared with T2 sagittal pelvic MRI image (Case 3A). Case 1-3C: Histopathological biopsy images of hematoxylin and eosin stain from case 1 (× 100), 2 (× 100), and 3 (× 100) showed poorly-differentiated squamous cell carcinoma of cervix. Case 1D: Histopathological images of the surgical specimens (hematoxylin and eosin stain, × 100) revealed a pathological disappearance of all tumor lesions after combined neoadjuvant treatment, compared to pretreatment. Case 2, 3D: Histopathological images of the surgical specimens (hematoxylin and eosin stain, × 100) after combined neoadjuvant treatment showed partial pathological responses in case 2 and 3. 18F-FDG PET/CT, 18fluoro-deoxyglucose positron emission tomography/computed tomography; MRI, magnetic resonance imaging