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Fig. 1 | Diagnostic Pathology

Fig. 1

From: Identification of dual STRN-NTRK2 rearrangements in a high grade sarcoma, with good clinical response to first-line larotrectinib therapy

Fig. 1

Clinical timeline (A) and imaging (B-E). Before treatment (B: - Day 50 & C: Day 0), a heterogenous mass (yellow arrows in B-E) centers in the right gluteus medius and maximus muscles with extension into the right paraspinal musculature, and invasion of the right posterior iliac bone. Imaging on post-treatment Day 60 (D) and Day 170 (E) show significant decrease in tumor size (MRI#4 of Day 80 is not shown here). 130 days after surgery, a 6.9 cm solid mass in the lower lobe of left lung is biopsied and proven to be a metastatic lesion (F, Day 320, blue arrow with circle), with near complete resolution after the resumption of Larotretinib treatment (G: Day 455, blue arrow with circle & H: Day 560)

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Diagnostic Pathology

ISSN: 1746-1596

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