Table 1 Review of reported NTRK2 fusion tumors with different partner genes
ID | Partner genes | Tumor types (Refs) | Tumor location(s) |
|---|---|---|---|
1 (including current case) | STRN | Sarcoma (current case, 14), Glioneuronal tumor (12) | Gluteal / Pelvic(current case), retroperitoneal, CNS |
2 | RBPMS | Sarcoma (3) | soft tissue |
3 | WWOX | Sarcoma (9) | Uterine |
4 | GNAQ | Sarcoma (3) | Bone |
5 | DAB2IP | Squamous cell carcinoma, Breast carcinoma, Lung adenocarcinoma (3) | Colorectal, Breast, Lung |
6 | TRAF2 | Melanoma (3) | Skin |
7 | PAN3 | Squamous cell carcinoma (3) | Head & neck |
8 | ETV6 | AML (3) | Hematologic |
9 | SQSTM1 | Glioma, Lung adenocarcinoma (1) | CNS, Lung |
10 | TRIM24 | Ganglioglioma, Lung adenocarcinoma (10) | CNS, Lung |
11 | BCR | Glioma, Gangliocytoma (1) | CNS |
12 | C2orf44 | Glioma (10) | CNS |
13 | KANK1 | Glioma (10) | CNS |
14 | AFAP1 | Glioma (3) | CNS |
15 | AGBL4 | Glioma (3) | CNS |
16 | GKAP1 | Glioma (1) | CNS |
17 | QKI | Glioma (10) | CNS |
18 | KCTD8 | Glioma (1) | CNS |
19 | NACC2 | Glioma (3) | CNS |
20 | NOS1AP | Glioma (1) | CNS |
21 | PRKAR2A | Glioma (1) | CNS |
22 | VCL | Glioma (3) | CNS |
23 | VCAN | Glioma (1) | CNS |
24 | TBC1D2 | Glioma (1) | CNS |
25 | KCTD16 | Ganglioglioma (10) | CNS |
26 | STRN3 | Ganglioglioma (11) | CNS |
27 | SPECC1L | Glioneuronal tumor (10) | CNS |
28 | WNK2 | Glioneuronal tumor (11) | CNS |
29 | TLE4 | Ganglioglioma (3) | CNS |
30 | ACO1 | Not specified (8) | Not specified |
31 | CTDSP2 | Not specified (8) | Not specified |
32 | DENND1A | Not specified (8) | Not specified |
33 | FAM117B | Not specified (8) | Not specified |
34 | NAV1 | Not specified (3) | Not specified |
35 | NOD1 | Not specified (8) | Not specified |
36 | PAIP1 | Not specified (8) | Not specified |
37 | PCSK5 | Not specified (8) | Not specified |
38 | PPP6R3 | Not specified (8) | Not specified |
39 | PRRX1 | Not specified (8) | Not specified |
40 | SLMAP | Not specified (3) | Not specified |
41 | THADA | Not specified (8) | Not specified |
42 | TRIP13 | Not specified (8) | Not specified |