Table 1 Histopathologic criteria for the diagnosis of diffuse nesidioblastosis in adults (recently known as ANHH) proposed by Anlauf et al.
MAJOR CRITERIA | MINOR CRITERIA |
|---|---|
Exclusion of an insulinoma by macroscopic, microscopic, and immunohistochemical examinations | Irregular shape and occasional enlargement of islets |
Multiple β-cells with an enlarged and hyperchromatic nucleus and abundant clear cytoplasm | Increased number of islets |
Islets with normal spatial distribution of the various cell types | Lobulated islet structure |
No proliferative activity of endocrine cells | Macronucleoli in β-cells |