Table 4 Concordance with each major and minor diagnostic criteria of ANHH in the current cases

Case

1

2

3

4

1

2

3

4

5

Exclusion of an insulinoma

P

P

P

P

P

P

P

P

P

Multiple β-cells with an enlarged nucleus

(Diameter of nucleus is more than 15 μm)

P

N

P

P

N

P

P

P

P

Multiple β-cells with a hyperchromatic nucleus

P

P

P

P

N

P

P

P

N

Multiple β-cells with an abundant cytoplasm

P

P

P

P

P

P

P

P

P

Islets with normal spatial distribution of the various cell types

P

P

P

P

P

P

P

P

P

No proliferative activity of endocrine cells

P

P

P

P

P

P

P

P

P

Macronucleoli

(Diameter of nucleolus is more than 5 μm)

P

N

P

N

N

P

P

N

N

Ductuloinsular complex

N

P

P

P

N

N

N

N

N