Evaluation of ARK5 and SIRT3 expression in renal cell carcinoma and their clinical significance

Diagnostic Pathology

Table 5 Correlation between H score of ARK5 and SIRT3 expression and clinicopathological parameters

	ARK5- H -score Mean ± SD	SIRT3- H -score Mean ± SD	Test	P value
Gender
Male	163.7 ± 57.7	128.6 ± 83.2	Mann–Whitney	P1 = 0.85 P2 = 0.82
Female	165.7 ± 53.2	144.5 ± 78.9	Mann–Whitney	P1 = 0.85 P2 = 0.82
Histological type clear	154.8 ± 66.3	128.4 ± 88.4	Kruskal–Wallis	P1 = 0.11 P2 = 0.13
Papillary	160.0 ± 30.0	77.1 ± 77.8
Chromophobe	191.6 ± 31.8	172.5 ± 39.2
Others	133.3 ± 28.8	133.3 ± 115.9
Tumour grade
1	118.0 ± 69.9	114.67 ± 74.7	Kruskal–Wallis	P1 = 0.01* P2 = 0.037*
2	175.2 ± 38.68	115.7 ± 88.8
3	187.86 ± 31.67	162.86 ± 64.97
4	182.5 ± 53.18	172.5 ± 83.96
Apoptosis	164.48 ± 55.6	134.66 ± 81.2	Pearson	P1 = 0.035 P2 = 0.016*
Mitosis	164.5 ± 55.6	134.66 ± 81.2	Pearson	P1 = 0.001** P2 = 0.002*
Tumour Extent
1	130.5 ± 67.2	92.5 ± 79.5	Kruskal–Wallis	P1 = 0.004* P2 = 0.001**
2	177.1 ± 37.0	133.8 ± 72.1
3	182.0 ± 37.8	187.0 ± 67.8
4	240.0 ± 21.2	230.0 ± 42.4
Stage
I	130.5 ± 67.2	92.5 ± 79.5	Kruskal–Wallis	P1 = 0.003* P2 = 0.001**
II	174.0 ± 35.0	132.5 ± 73.7
III	185.6 ± 39.3	176.9 ± 65.7
IV	240.0 ± 21.2	240.0 ± 42.4
Response to chemotherapy
No	200.4 ± 23.5	183.1 ± 62.1	Kruskal–Wallis	P1 = 0.013* P2 = 0.037*
Partial	177.4 ± 40.9	123.2 ± 82.5
Complete	141.7 ± 43.1	53.3 ± 88.5
ARK5 and SIRT3	164.5 ± 55.651	134.6 ± 81.2	Pearson correlation (R) 0.342	0.009*

ISSN: 1746-1596