Table 5 Comparison of the sensitivity, specificity, positive predictive value and negative predictive value of different Biomarker
From: Clinical value of Cyclin D1 and P21 in the differential diagnosis of papillary thyroid carcinoma
Diagnosis of PTC primary lesions | ||||
|---|---|---|---|---|
Biomarker | Se | Sp | PPV | NPV |
Cyclin D1 | 93.00% | 96.06% | 94.41% | 95.04% |
P21 | 88.50% | 99.28% | 98.89% | 92.33% |
Cyclin D1 + P21 | 96.00% | 95.69% | 94.12% | 97.09% |
CK19 + HBME-1 + Galectin-3 | 65.00% | 99.28% | 98.48% | 79.83% |
Differential diagnosis intralymph node PTC metastases and intralymph node ectopic thyroid tissue | ||||
Biomarker | Se | Sp | PPV | NPV |
Cyclin D1 | 97.96% | 73.33% | 92.31% | 91.67% |
P21 | 89.80% | 86.67% | 95.65% | 72.22% |
Cyclin D1 + P21 | 97.96% | 73.33% | 92.31% | 91.67% |