Table 1 The characteristics of patients BC in different HR status in Cohort 1

Age at diagnosis

20–30

220 (0.4)

62 (0.7)

8 (1.1)

130 (1.3)

 < 0.001

31–40

2014 (3.7)

381 (4.6)

67 (9.5)

870 (8.4)

41–50

9410 (17.7)

950 (11.4)

165 (23.4)

1940 (18.7)

51–60

13,711 (25.7)

2331 (28.1)

186 (26.4)

3034 (29.3)

61–70

16,733 (31.4)

2781 (33.5)

169 (24.0)

2829 (27.3)

71–80

11,211 (21.1)

1795 (21.7)

109 (15.6)

1560 (15.0)

Race

Black

3540 (6.6)

997 (12.0)

93 (13.2)

1553 (15.0)

 < 0.001

White

42,977 (80.6)

6255 (75.4)

535 (76.0)

7459 (72.0)

Others

6782 (12.8)

1048 (12.6)

76 (9.8)

1351 (13.0)

Histological grade

1

16,293 (3.6)

1509 (18.2)

11 (1.6)

159 (1.5)

 < 0.001

2

27,008 (50.7)

3424 (41.3)

127 (18.4)

1919 (18.5)

3

9998 (46.7)

3367 (40.5)

566 (80.0)

8285 (80.0)

T stage

1

36,432 (68.4)

4965 (59.8)

304 (43.2)

5022 (48.5)

 < 0.001

2

13,641 (25.6)

2600 (31.3)

322 (45.7)

4090 (39.5)

3

2536 (4.8)

554 (6.7)

52 (7.4)

840 (8.1)

4

690 (1.2)

181 (2.2)

26 (3.7)

411 (3.90)

N stage

0

40,502 (76.0)

6083 (73.3)

480 (68.2)

7058 (68.1)

 < 0.001

1

9385 (17.6)

1543 (18.6)

164 (23.2)

2336 (22.5)

2

2319 (4.4)

405 (4.9)

37 (5.3)

556 (5.4)

3

1093 (2.0)

269 (3.2)

23 (3.3)

413 (4.0)

HER-2

Positive

5311 (9.9)

1909 (23.0)

197 (28.0)

2966 (28.6)

 < 0.001

Negative

47,988 (90.1)

6391 (77.0)

507 (72.0)

7397 (71.4)

Stage

I

31,842 (59.7)

4314 (52.0)

252 (35.8)

4193 (40.5)

 < 0.001

II

16,643 (31.2)

2994 (36.1)

358 (50.8)

4561 (44.0)

III

4814 (9.1)

992 (11.9)

94 (13.4)

1609 (15.5)

Histological type

IDC

42,621 (80.0)

6697 (80.7)

671 (95.3)

10,035 (96.8)

 < 0.001

ILC

6422 (12.0)

1055 (12.7)

13 (1.8)

123 (1.2)

Others

4256 (8.0)

548 (6.6)

20 (2.9)

205 (2.0)