Table 3 Univariate analysis of the OS and the BCSS in Cohort 1

Age at diagnosis

20–30

Ref

Ref

31–40

0.796

0.611–1.038

0.092

0.859

0.644–1.145

0.300

41–50

0.482

0.374–0.622

 < 0.001

0.444

0.336–0.623

 < 0.001

51–60

0.592

0.463–0.765

 < 0.001

0.473

0.359–0.623

 < 0.001

61–70

0.744

0.580–0.955

0.020

0.396

0.300–0.521

 < 0.001

71–80

1.517

1.182–1.947

0.001

0.542

0.411–0.714

 < 0.001

Race

White

Ref

Ref

Black

1.728

1.627–1.835

 < 0.001

2.149

1.984–2.327

 < 0.001

Others

0.805

0.752–0863

 < 0.001

0.931

0.848–1.023

0.136

Histological grade

1

Ref

2

1.435

1.351–1.524

 < 0.001

2.471

2.202–2.772

 < 0.001

3

2.342

2.206–2.485

 < 0.001

6.389

5.721–7.135

 < 0.001

T stage

1

Ref

2

1.994

1.906–2.085

 < 0.001

3.830

3.573–4.105

 < 0.001

3

3.214

3.000–3.442

 < 0.001

7.738

7.075–8.464

 < 0.001

4

7.047

6.467–7.680

 < 0.001

17.291

15.543–19.236

 < 0.001

N stage

0

Ref

1

1.750

1.666–1.839

 < 0.001

3.188

2.977–3.414

 < 0.001

2

3.018

2.814–3.237

 < 0.001

6.288

5.759–6.866

 < 0.001

3

4.921

4.553–5.318

 < 0.001

11.135

10.14–12.220

 < 0.001

ER

Negative

Ref

Positive

0.528

0.503–0.553

 < 0.001

0.337

0.317–0.358

 < 0.001

PR

Negative

Ref

Positive

0.561

0.543–0.591

 < 0.001

0.361

0.341–0.383

 < 0.001

HER-2

Negative

Ref

Positive

0.990

0.934–1.050

0.737

1.158

1.070–1.253

 < 0.001

Stage

I

Ref

II

1.784

1.702–1.870

 < 0.001

3.899

3.599–4.224

 < 0.001

III

4.306

4.085–4.538

 < 0.001

12.911

11.901–14.005

 < 0.001

Histological type

IDC

Ref

ILC

1.015

0.949–1.084

0.672

1.009

0.918–1.109

1.009

Others

0.941

0.867–1.021

0.143

0.894

0.794–1.008

0.894

HR status

ER + /PR + 

Ref

ER + /PR-

1.508

1.420–1.601

 < 0.001

2.163

1.993–2.348

 < 0.001

ER-/PR + 

2.036

1.721–2.409

 < 0.001

3.435

2.798–4.217

 < 0.001

ER-/PR-

2.020

1.922–2.124

 < 0.001

3.419

3.201–3.652

 < 0.001