Table 1 Clinical and pathological features of NFATC2-rearranged sarcomas (including previous reported cases and cases from this study)
From: Report and literature review of four cases of EWSR1::NFATC2 round cell sarcoma
Study | Case | Age(y)/sex | Primary location | Local recurrence (mo) | Metastatic | Therapy | Outcome(months)/status |
|---|---|---|---|---|---|---|---|
Current study | 1 | 26/M | Femur | Yes(23) | Yes | Surgery + CT | 84/AWD |
2 | 20/M | Femur | Yes(72) | No | nCT + Surgery + RT | 180/AWD | |
3 | 14/M | Femur | No | No | nCT + Surgery | 26/AWOD | |
4 | 32/F | Femur | No | No | Surgery | 61/AWOD | |
Makise. [7] | 5 | 26/F | Femur | Yes(24) | No | Surgery | NR |
Perreta. [8] | 6 | 27/M | Tibia | No | No | nCT + Surgery | 102/AWOD |
7 | 66/F | Femur | Yes(4) | Yes | Surgery | 32/DOD | |
8 | 28/F | Tibia | No | No | nCT + Surgery | 5/AWOD | |
9 | 19/F | Ilium | - | No | nCT + RT | 8/AWD | |
10 | 58/M | Femur | - | No | nCT + Surgery | Recent case | |
Yoshida. [9] | 11 | 39/M | Femur | NR | NR | NR | NR |
12 | 46/M | Femur | NR | NR | NR | NR | |
13 | 27/M | Retroperitoneum | NR | NR | NR | NR | |
14 | 31/F | Scapula | NR | NR | NR | NR | |
15 | 36/M | Neck | NR | NR | NR | NR | |
16 | 51/M | Forearm | NR | NR | NR | NR | |
17 | 78/F | Tibia | NR | NR | NR | NR | |
18 | 38/M | Thigh | NR | NR | NR | NR | |
19 | 44/M | Thigh | NR | NR | NR | NR | |
20 | 36/M | Fibula | NR | NR | NR | NR | |
21 | 62/F | Femur | NR | NR | NR | NR | |
22 | 49/M | Femur | NR | NR | NR | NR | |
Diza-Perez. [10] | 23 | 28/M | Tibia | No | No | nCT + RT + Surgery | 144/AWOD |
24 | 39/M | Femur | No | No | nCT + RT + Surgery | 30/AWOD | |
25 | 28/M | Humerus | No | No | nCT + RT + Surgery | Recent case | |
26 | 46/M | Femur | Yes(5.9) | Yes | nCT + RT + Surgery | 5.9/AWD | |
Wang. [11] | 27 | 67/M | Radius | No | No | nCT + Surgery | 14/AWOD |
28 | 32/M | Periclavicular | No | No | nCT + RT + Surgery | 24/AWOD | |
29 | 42/M | Radius | No | Yes | nCT + Surgery | 16/AWD | |
30 | 24/F | Gastrocnemius muscle | No | No | nCT + Surgery | 23/AWOD | |
31 | 42/M | Radius | No | Yes | nCT + Surgery | 93/DOD | |
32 | 59/M | Periclavicular | Yes(6) | No | nCT + RT + Surgery | 144/AWOD | |
Koelscheb. [12] | 33 | 51/M | Humerus | Yes(24)(n = 1) | Yes(n = 1) | nCT + Surgery | NA/AWOD(n = 1) |
34 | 56/F | Femur | No(n = 2) | No(n = 2) | (n = 3) | 72/Alive(n = 1) | |
35 | 17/F | Humerus | 24/Alive(n = 1) | ||||
Mantilla. [13] | 36 | 67/M | Thigh | NR | NR | Surgery | LOST |
Bode-Lesniewska. [14] | 37 | 34/F | Femur | NR | Yes | nCT + Surgery | 132/AWOD |
38 | 42/M | Tibia | No | No | Surgery | 102/AWOD | |
39 | 60/F | Intra-abdominal | No | No | Surgery | 8/AWOD | |
40 | 12/M | Humerus | No | No | Surgery | 8/AWOD | |
Yau. [15] | 41 | 43/M | Femur | No | No | RT, nCT + Surgery | 12/AWOD |
Watson. [16] | 42 | 49/F | Femur | NR | NR | NR | NR |
43 | 32/M | Humerus | NR | NR | NR | NR | |
44 | 12/F | Tibia | NR | NR | NR | NR | |
45 | 61/M | Calf | NR | NR | NR | NR | |
46 | 23/M | Femur | NR | NR | NR | NR | |
47 | 33/M | Femur | NR | NR | NR | NR | |
48 | 43/M | Femur | NR | NR | NR | NR | |
Toki. [17] | 49 | NR | NR | NR | NR | NR | NR |
Antonescu. [18] | 50 | 42/M | Femur | NR | NR | NR | NR |
Machado. [19] | 51 | NR | Fibula | NR | NR | NR | NR |
Cohen. [20] | 52 | 24/F | Calf | No | No | nCT + Surgery | 12/AWOD |
Brohl. [21] | 53 | 15/M | Femur | NR | NR | NR | NR |
Kinkor. [22] | 54 | 12/M | Femur | No | No | nCT + Surgery | 11/AWOD |
55 | 28/M | Humerus | Yes | Suspicious lung | Surgery + metastatic CT | 53/AWD | |
Sadri. [23] | 56 | 30/M | Femur | Yes(30) | No | Surgery + CT | 36/AWOD |
Romeo. [24] | 57 | 32/M | Bone | NR | No | NR | 64/AWOD |
Szuhai. [6] | 58 | 39/M | Humerus | NR | NR | NR | NR |
59 | 16/M | Femur | NR | NR | NR | NR | |
60 | 21/M | Thigh soft tissue | NR | NR | NR | NR | |
61 | 25/M | Femur | NR | NR | NR | NR |