Fig. 2

Hemodiluted BM aspirate (A) showed predominant erythroid precursors with a full range of maturation without dysplasia and no excess in blasts (Wright Giemsa Stain, original magnification x400). BM core biopsy (B) revealed hypercellular marrow with erythroid hyperplasia (90% of cellularity) at various maturing stages, markedly decreased myeloid cells with a reversed M:E ratio of 1:10 (hematoxylin-eosin, original magnification x200). The significantly increased erythroid cells were highlighted by CD71 (C), in which approximately 10% erythroid precursors demonstrated by E-cadherin (D). TP53 is negative (C, inset). CD61 (E) showed megakaryocytes with overall unremarkable morphology (original magnification x200). Chromosomal analysis (F) depicted Ph chromosome t(9; 22) detected in 19 out of 20 cells (arrow head), along with inv9 (p12q13) in all metaphase cells, a common chromosomal variant without clinical significance (arrow)