Table 1 Summary of clinicopathologic features of collected pulmonary hyalinizing clear cell carcinoma

[1]

66F;

Ex-smoker

1.3 cm;

trachea

EWSR1 gene rearrangement

Laser therapy + cryotherapy

NM

NM

[4]

38 M;

Non-smoker

2.6 cm;

trachea

EWSR1 gene rearrangement

EWSR1::ATF1 gene fusion

Lobectomy

NM

No recurrence or metastasis after 10 mo

[5]

56F;

Non-smoker

3.3 cm;

right segmental bronchus

EWSR1 gene rearrangement

EWSR1::ATF1 gene fusion

Lobectomy

( +)

No recurrence or metastasis after 12 mo

[5]

35F;

Smoker

2.8 cm;

right segmental bronchus

EWSR1 gene rearrangement

EWSR1::ATF1 gene fusion

Lobectomy

(-)

No recurrence or metastasis after 79 mo

[5]

52F;

Non-smoker

3.3 cm;

right segmental bronchus

EWSR1 gene rearrangement

EWSR1::ATF1 gene fusion

Lobectomy

NM

No recurrence or metastasis after 181 mo

[6]

Sex F: M = 5:3

Average age: 58 years

Non-smoker: smoker = 7:1

Average size:2.1 cm

right lung: left lung: trachea

 = 4:3:1

8 cases EWSR1 gene rearrangement

5 cases EWSR1::ATF1 fusion gene (one with an ATF1::SPTLC2 gene)

1 cases EWSR1::CREM fusion gene

2 cases no mention

Lobectomy

1/8( +)

7/8(-)

1 case was lost, 7 patients were followed up for 6 to 45 months, all without recurrence

[7]

54F;

ex-smoker

3.5 cm;

Left upper lung lobe

EWSR1 gene rearrangement

EWSR1::ATF1 gene fusion

lobectomy

(-)

No recurrence or metastasis after 16 mo

[12]

44 M;

Non-smoker

3.5 cm;lobar bronchus

(left lower)

EWSR1 gene rearrangement

Lobectomy

NM

Recurrence-free 4 years after surgery

[12]

56F;Non-smoker

1.6 cm;lobar bronchus

(left upper)

EWSR1 gene rearrangement

Lobectomy

NM

NM

[12]

44F;Non-smoker

1.3 cm; lobar bronchus

(right upper)

EWSR1 gene rearrangement

Lobectomy

NM

NM

[12]

33F;Non-smoker

4.9 cm; lobar bronchus

(right middle)

EWSR1 gene rearrangement

Lobectomy

NM

NM

[12]

64 M;Non-smoker

4.9 cm;left upper lobe hilm

EWSR1 gene rearrangement

Lobectomy

 + chemotherapy

( +)

Recurrence free 9 month after surgery

[13]

57F;Ex-smoker

2.8 cm; right lower lobe

EWSR1 gene rearrangement;

EWSR1::ATF1 gene fusion

Lobectomy

( +)

No recurrence or metastasis after 3mo

[14]

53 M;Non-smoker

1.6 cm; bronchus

EWSR1 gene rearrangement;

EWSR1::ATF1 gene fusion

Lobectomy

( +)

Metastasis after 192 mo

[15]

32 M;Non-smoker

1.8 cm; left lower lobe

EWSR1 gene rearrangement

Lobectomy

(-)

No recurrence or metastasis after 18 mo

[15]

39 M; Non-smoker

2.6 cm;right lower lobe

EWSR1 gene rearrangement

Lobectomy

(-)

No recurrence or metastasis after 18 mo

[16]

55 M;Ex-smoker

2.5 cm; bronchus

EWSR1 gene rearrangement

Lobectomy

(-)

No recurrence or metastasis after 20 mo

[17]

58 M;Non-smoker

4.3 cm; right upper lobe

EWSR1 gene rearrangement;

EWSR1::ATF1 gene fusion

lobectomy + Chemotherapy

NM

No recurrence or metastasis after 10 mo

[17]

60F;Non-smoker

2 cm; left lower lobe

EWSR1 gene rearrangement;

EWSR1::ATF1 gene fusion

lobectomy + lymphadenectomy

(-)

No recurrence or metastasis after 10 mo

[18]

55F;smoker

2.5 cm; trachea

EWSR1 gene rearrangement

Resection + radiation therapy

(-)

No recurrence or metastasis after 12 mo

[19]

46F;Non-smoker

Size no mention; trachea

EWSR1 gene rearrangement;

EWSR1::ATF1 gene fusion

Resection + chemoradiation

(-)

Deceased 6 years after first diagnosis

[20]

64F;Non-smoker

4.2 cm; left upper lobe of lung

EWSR1::CREM gene fusion

Lobectomy + lymph node dissection

(-)

No recurrence or metastasis after 2 mo

[21]

66 M;Ex-smoker

3.3 cm; right main bronchus

EWSR1 gene rearrangement;

EWSR1::ATF1 gene fusion

Resection

NM

Recurrence after 2 years

[21]

48F;Non-smoker

2 cm; right middle lobe

EWSR1 gene rearrangement;

EWSR1::ATF1 gene fusion

Double lobectomy of right middle and lower lobe

NM

No recurrence or metastasis after 14 mo

[22]

75F;

Smoker history no mention

0.9 cm;

lower lobe of the lung

FISH: EWSR1 gene rearrangement; EWSR1::CREM gene fusion

Lobectomy

(-)

No evidence of disease at 8 mo postsurgery

[23]

81 M;Non-smoker

2.9 cm; right upper lung

EWSR1::ATF1 gene fusion

Lobectomy + lymph node dissection

( +)

No recurrence or metastasis after 9 mo

[24]

54F;Non-smoker

2.5 cm; right Upper Lung Lobe

EWSR1 gene rearrangement;

EWSR1::ATF1 gene fusion

Lobectomy + regional lymph node dissection

(-)

No recurrence or metastasis after 8 mo

Summary

F:M = 21:13

Average size:2.6 cm

FISH: 33 cases EWSR1 gene rearrangement

EWSR1::ATF1:EWSR1::CREM = 19:3

Lobectomy(main)

Rarely suffer

Positive prognosis