Fig. 2From: Cerebrospinal fluid and blood exosomes as biomarkers for amyotrophic lateral sclerosis; a systematic reviewThe ALS disease pathological signaling pathway. MFG-E8: milk fat globule-EGF factor 8, PGRN: Progranulin, MCP-1: macrophage chemoattractant protein-1, MIP-1β: macrophage inflammatory protein-1β, ROS: reactive oxygen species, SOD1: Superoxide dismutase 1, FUS: Fused in sarcoma, TDP-43: TAR DNA-binding protein 43, NFL: neurofilament light, NFH: neurofilament heavy, DPRs: dipeptide repeat proteinsBack to article page