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COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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  2. Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their m...

    Authors: Wenzel M. Hackeng, Ralph H. Hruban, G. Johan A. Offerhaus and Lodewijk A. A. Brosens
    Citation: Diagnostic Pathology 2016 11:47
    Content type: Review Published on:

  4. Carbonic anhydrase IX is a member of α-carbonic anhydrases that is preferentially expressed in solid tumors. It enables bicarbonate transport across the plasma membrane, neutralizing intracellular pH and confe...

    Authors: Maria Raffaella Ambrosio, Claudia Di Serio, Giovanna Danza, Bruno Jim Rocca, Alessandro Ginori, Igor Prudovsky, Niccolò Marchionni, Maria Teresa del Vecchio and Francesca Tarantini
    Citation: Diagnostic Pathology 2016 11:45
    Content type: Research Published on:

  5. Programmed Death Ligand 1 (PD-L1) is an immune modulating protein expressed on the surface of various inflammatory cells, including T Cells, B Cells, dendritic cells, and macrophages. PD-L1 represents an impor...

    Authors: Jacquelyn Smith, Mark D. Robida, Krista Acosta, Bharathi Vennapusa, Amita Mistry, Greg Martin, Alton Yates and H. James Hnatyszyn
    Citation: Diagnostic Pathology 2016 11:44
    Content type: Research Published on:

  6. Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized inflammatory condition with single- or multi-organ involvement. The disease is characterized by tumefactive lesions with dense IgG4 plasmacy...

    Authors: Moriyoshi Nakamura, Osamu Iwamoto, Takahiro Chino, Keita Todoroki and Jingo Kusukawa
    Citation: Diagnostic Pathology 2016 11:43
    Content type: Case Report Published on:

  7. Survival of glioma patients with the same tumor histology and grade can vary significantly, and some low-grade gliomas transform to a more malignant phenotype. There is a need of molecular signatures, which ar...

    Authors: Giedrius Steponaitis, Daina Skiriutė, Arunas Kazlauskas, Ieva Golubickaitė, Rytis Stakaitis, Arimantas Tamašauskas and Paulina Vaitkienė
    Citation: Diagnostic Pathology 2016 11:42
    Content type: Research Published on:

  9. Ectopic (accessory) adrenocortical tissue, also known as adrenal rests, is a developmental abnormality of the adrenal gland. The most common ectopic site is in close proximity to the adrenal glands and along t...

    Authors: Yang Liu, Yue-Feng Jiang, Ye-Lin Wang, Hong-Yi Cao, Liang Wang, Hong-Tao Xu, Qing-Chang Li, Xue-shan Qiu and En-Hua Wang
    Citation: Diagnostic Pathology 2016 11:40
    Content type: Case Report Published on:

  10. BRAF (V-raf murine sarcoma viral oncogene homolog B1) is a serine-threonine protein kinase involved in cell survival, proliferation, and differentiation. The most common missense mutation of BRAF (mainly V600E) c...

    Authors: Michiko Tatsuno, Yoko Shioda, Hideto Iwafuchi, Shigeki Yamazaki, Kenta Iijima, Chiaki Takahashi, Hiromi Ono, Kiyono Uchida, Osamu Okamura, Mamoru Matubayashi, Torayuki Okuyama, Kimikazu Matsumoto, Takako Yoshioka and Atsuko Nakazawa
    Citation: Diagnostic Pathology 2016 11:39
    Content type: Methodology Published on:

  11. Although asbestos acts as a potent carcinogen in pleural mesothelial and pulmonary epithelial cells, it still remains unclear whether asbestos causes specific and characteristic gene alterations in these diffe...

    Authors: Tomoaki Naka, Yutaka Hatanaka, Katsuji Marukawa, Hiromi Okada, Kanako C. Hatanaka, Jun Sakakibara-Konishi, Satoshi Oizumi, Yasuhiro Hida, Kichizo Kaga, Tomoko Mitsuhashi and Yoshihiro Matsuno
    Citation: Diagnostic Pathology 2016 11:38
    Content type: Case Report Published on:

  12. Fluorescence in situ hybridization (FISH) is one of the most powerful genetic analysis tools for pathological diagnoses. FISH can detect various genetic abnormalities including gene translocation that was specifi...

    Authors: Shintaro Sugita, Hiroko Asanuma and Tadashi Hasegawa
    Citation: Diagnostic Pathology 2016 11:37
    Content type: Research Published on:

  13. The clear cell/signet-ring cell variant of cutaneous squamous cell carcinoma (cSCC) is extremely rare. Its carcinogenesis has consistently been linked to ultraviolet radiation and HPV in the literature. Howeve...

    Authors: Nong-Rong Wang, Meng-Meng Wang, Lv Zhou, Ze-Lin Liu, Nan-Ping Chen, Jin-Ping Hu, Yan-Juan Deng, Xiao-Qing Qi, Xiao-Feng Huang, Yue Su, Si-Yao Zhang, Fei Tong, Yu Zhang, Qi Lu, Zi-Yu Zhu and Huan Deng
    Citation: Diagnostic Pathology 2016 11:36
    Content type: Case Report Published on:

  14. Staging of melanoma includes quantification of a proliferation index, i.e., presumed melanocytic mitoses of H&E stains are counted manually in hot spots. Yet, its reproducibility and prognostic impact increase...

    Authors: Patricia Switten Nielsen, Rikke Riber-Hansen, Henrik Schmidt and Torben Steiniche
    Citation: Diagnostic Pathology 2016 11:35
    Content type: Methodology Published on:

  15. In cancer, various MMPs play a role in progression and metastasis and their overexpression generally indicates a poor prognosis. MMP-14 is the main activator of MMP-2 and both molecules play a role in normal o...

    Authors: M. Caroline Vos, Anneke A. M. van der Wurff, Johan Bulten, Roy Kruitwagen, Harrie Feijen, Toin H. van Kuppevelt, Thijs Hendriks and Leon F. A. G. Massuger
    Citation: Diagnostic Pathology 2016 11:34
    Content type: Research Published on:

  18. The counting of poorly differentiated clusters of 5 or more cancer cells lacking a gland-like structure in a tumor mass has recently been identified among the histological features predictive of poor prognosis...

    Authors: Luca Reggiani Bonetti, Valeria Barresi, Stefania Bettelli, Federica Domati and Cristian Palmiere
    Citation: Diagnostic Pathology 2016 11:31
    Content type: Review Published on:

  19. Ovarian epithelial cancers are among the most lethal women's cancers. There is no doubt about the preventive role of oral contraceptive pills (OCPs) in development of ovarian cancers. But, there are limited nu...

    Authors: Ali DastranjTabrizi, Parvin MostafaGharabaghi, Farzam SheikhzadehHesari, Liela Sadeghi, Sharareh Zamanvandi, Parvin Sarbakhsh and Morteza Ghojazadeh
    Citation: Diagnostic Pathology 2016 11:30
    Content type: Research Published on:

  20. Vitreoretinal lymphoma (VRL) is a life- and sight-threatening disorder. The aim of this study was to analyze the usefulness of the cell block method for diagnosis of VRL.

    Authors: Satoru Kase, Kenichi Namba, Daiju Iwata, Kazuomi Mizuuchi, Nobuyoshi Kitaichi, Yoshiaki Tagawa, Hiromi Okada-Kanno, Yoshihiro Matsuno and Susumu Ishida
    Citation: Diagnostic Pathology 2016 11:29
    Content type: Research Published on:

  21. New sequencing technologies have enabled the identification of mutations in Ten-eleven-translocation 2 (TET2), an enzyme that catalyzes the conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5-hmC) in m...

    Authors: Renata Scopim-Ribeiro, João Agostinho Machado-Neto, Paula de Melo Campos, Fernanda Soares Niemann, Irene Lorand-Metze, Fernando Ferreira Costa, Sara Teresinha Olalla Saad and Fabiola Traina
    Citation: Diagnostic Pathology 2016 11:28
    Content type: Short report Published on:

  22. Four subtypes of hepatocellular adenomas (HCA) are recognized: hepatocyte-nuclear-factor-1α mutated (H-HCA), β-catenin-mutated type with upregulation of glutamine synthetase (b-HCA), inflammatory type (IHCA) w...

    Authors: Elizabeth Margolskee, Fei Bao, Anne Koehne de Gonzalez, Roger K. Moreira, Stephen Lagana, Anthony N. Sireci, Antonia R. Sepulveda, Helen Remotti, Jay H. Lefkowitch and Marcela Salomao
    Citation: Diagnostic Pathology 2016 11:27
    Content type: Research Published on:

  23. Phosphaturic mesenchymal tumors (PMTs) are rare neoplasms that are often associated with tumor-induced osteomalacia (TIO) due to excessive serum levels of fibroblast growth factor 23 (FGF23). PMTs share overla...

    Authors: Eisuke Shiba, Atsuji Matsuyama, Ryo Shibuya, Kei Yabuki, Hiroshi Harada, Mitsuhiro Nakamoto, Takahiko Kasai and Masanori Hisaoka
    Citation: Diagnostic Pathology 2016 11:26
    Content type: Research Published on:

  26. Patients with non-dysplastic Barrett’s esophagus (ND-BE) and low-grade dysplasia (LGD) are typically monitored by periodic endoscopic surveillance, while those with high-grade dysplasia (HGD) and esophageal ad...

    Authors: Dipti M. Karamchandani, Heather L. Lehman, Sara E. Ohanessian, Julie Massé, Patricia A. Welsh, Robert D. Odze, John R. Goldblum, Arthur S. Berg and Douglas B. Stairs
    Citation: Diagnostic Pathology 2016 11:23
    Content type: Research Published on:

  27. Myolipoma of soft tissue is an extremely rare benign tumor composed of mature adipose tissue and smooth muscle cells. It is found predominantly in women. The cytogenetic and molecular genetic features of myoli...

    Authors: Ioannis Panagopoulos, Ludmila Gorunova, Antonio Agostini, Ingvild Lobmaier, Bodil Bjerkehagen and Sverre Heim
    Citation: Diagnostic Pathology 2016 11:22
    Content type: Research Published on:

  28. Mutations in the TERT promoter, ALK rearrangement, and the BRAF V600E mutation are associated with aggressive clinicopathologic features in thyroid cancers. However, little is known about the impact of TERT promo...

    Authors: Ja Seong Bae, Yourha Kim, Sora Jeon, Se Hee Kim, Tae Jung Kim, Sohee Lee, Min-Hee Kim, Dong Jun Lim, Youn Soo Lee and Chan Kwon Jung
    Citation: Diagnostic Pathology 2016 11:21
    Content type: Research Published on:

  29. Pregnancies affected by non-molar chromosomal abnormality may sometimes demonstrate abnormal chorionic villous morphology that is similar to partial hydatidiform mole. Determination of the underlying aetiology...

    Authors: Neil J Sebire, Philippa C May, Baljeet Kaur, Michael J Seckl and Rosemary A Fisher
    Citation: Diagnostic Pathology 2016 11:20
    Content type: Case Report Published on:

  30. The 5-year survival rate of patients with hepatocellular cancer (HCC) was very low because of invasion and metastasis in the early stage. Biomarkers might help predict early occurrence of invasion and metastas...

    Authors: L. J. Song, Q. Liu, X. R. Meng, SH. L Li, L. X. Wang, Q. X. Fan and X. Y. Xuan
    Citation: Diagnostic Pathology 2016 11:19
    Content type: Research Published on:

  31. Massive ovarian oedema is a rare non-neoplastic clinicopathologic entity has a higher incidence in women during their second and third life decade. The oedema can be presented in one or both ovaries as a resul...

    Authors: Nikolaos Machairiotis, Aikaterini Stylianaki, Paraskevi Kouroutou, Polixeni Sarli, Nikolaos Konstantinos Alexiou, Elias Efthymiou, Athanasios Maras, Nikolaos Georgios Alexiou, Spyridon Evaggelos Nikolaou, Nikolaos Courcoutsakis, Eleni Papakonstantinou, Paul Zarogoulidis, Nikolaos Barbetakis, Dimitrios Paliouras, Apostolos Gogakos and Christodoulos Machairiotis
    Citation: Diagnostic Pathology 2016 11:18
    Content type: Case Report Published on:

  32. Ovarian clear cell carcinoma (CCC) is an uncommon subtype of ovarian epithelial tumor. The prognostic significance of its clinicopathological parameters is discordant, with the exception of stage as the advers...

    Authors: Rui Bi, Xuxia Shen, Weiwei Zhang, Yufan Cheng, Zheng Feng, Xu Cai and Wentao Yang
    Citation: Diagnostic Pathology 2016 11:17
    Content type: Research Published on:

  33. Endometrial mixed carcinoma with the neuroendocrine carcinoma (NEC) component is rare and is believed to have a poor prognosis. CD10 expression is reported to be a favorable prognostic marker for some tumors s...

    Authors: Karina Uehara, Fukino Ikehara, Yasuka Tanabe, Iwao Nakazato, Mariko Oshiro, Morihiko Inamine and Takao Kinjo
    Citation: Diagnostic Pathology 2016 11:16
    Content type: Case Report Published on:

  34. Aberrant α-synuclein aggregation due to the deficiency of ubiquitin-proteasome or of autophagy characterizes the parkinson disease (PD). High mobility group box 1 (HMGB1) is a novel stress sensor to mediate th...

    Authors: Kaihua Wang, Jianmin Huang, Wei Xie, Longjian Huang, Canhua Zhong and Zhenzhen Chen
    Citation: Diagnostic Pathology 2016 11:15
    Content type: Research Published on:

  35. TRPV6 is over-expressed and promotes the proliferation and invasion in many cancers. The association between the expression of TRPV6 and clinical outcome in esophageal squamous cell carcinoma (ESCC) has not be...

    Authors: Shui-Shen Zhang, Xuan Xie, Jing Wen, Kong-Jia Luo, Qian-wen Liu, Hong Yang, Yi Hu and Jian-Hua Fu
    Citation: Diagnostic Pathology 2016 11:14
    Content type: Research Published on:

  36. Molecular profiling has uncovered genetic subtypes of glioblastoma (GBM), including tumors with IDH1 mutations that confer increase survival and improved response to standard-of-care therapies.  By mapping the g...

    Authors: Phedias Diamandis, Ruben Ferrer-Luna, Raymond Y. Huang, Rebecca D. Folkerth, Azra H. Ligon, Patrick Y. Wen, Rameen Beroukhim, Keith L. Ligon and Shakti H. Ramkissoon
    Citation: Diagnostic Pathology 2016 11:13
    Content type: Case Report Published on:

  38. Genomic techniques in recent years have allowed the identification of many mutated genes important in the pathogenesis of acute myeloid leukemia (AML). Together with cytogenetic aberrations, these gene mutatio...

    Authors: Chun Hang Au, Anna Wa, Dona N. Ho, Tsun Leung Chan and Edmond S. K. Ma
    Citation: Diagnostic Pathology 2016 11:11
    Content type: Research Published on:

  39. Somatostatin receptor 2 (SSTR2) encodes somatostatin receptor that can inhibit the cell proliferation of solid tumors. Promoter hypermethylation is likely to silence the expression of SSTR2. The goal of our study...

    Authors: Zhisen Shen, Xiaoying Chen, Qun Li, Chongchang Zhou, Jinyun Li, Huadan Ye and Shiwei Duan
    Citation: Diagnostic Pathology 2016 11:10
    Content type: Research Published on:

  41. Sensitive and efficient detection of Group B Streptococcus (GBS) colonization in pregnant women is essential for prescription of prophylaxis at the time of delivery as GBS is an opportunistic pathogen known to ca...

    Authors: Yun Xie, JunLan Yang, Peng Zhao, Hui Jia and Qi Wang
    Citation: Diagnostic Pathology 2016 11:8
    Content type: Short report Published on:

  42. Solid pseudopapillary neoplasm is a rare cystic tumor of the exocrine pancreas. Abdominal pain or discomfort is the most common symptom, usually in young females.

    Authors: Rick Bidassek, Herbert Spelter, Daniel Gödde, Hubert Zirngibl and Peter C. Ambe
    Citation: Diagnostic Pathology 2016 11:7
    Content type: Case Report Published on:

  43. When treating bladder cancer patients, the most significant problems usually concern cases with high-grade non-muscle-invasive carcinoma, and a better understanding of which patients would benefit from early r...

    Authors: Carlo Patriarca, Rodolfo Hurle, Marco Moschini, Massimo Freschi, Piergiuseppe Colombo, Maurizio Colecchia, Lucia Ferrari, Giorgio Guazzoni, Andrea Conti, Giario Conti, Roberta Lucianò, Tiziana Magnani and Renzo Colombo
    Citation: Diagnostic Pathology 2016 11:6
    Content type: Research Published on:

  44. Integrated molecular pathology (IMP) approaches based on DNA mutational profiling accurately determine pancreatic cyst malignancy risk in patients lacking definitive diagnoses following endoscopic ultrasound i...

    Authors: David Loren, Thomas Kowalski, Ali Siddiqui, Sara Jackson, Nicole Toney, Nidhi Malhotra and Nadim Haddad
    Citation: Diagnostic Pathology 2016 11:5
    Content type: Research Published on:

  45. Syphilitic orchitis is a rare manifestation of gumma in tertiary syphilis, microscopically typically characterized by multiple discrete granulomas with central necrosis and peripheral fibrosis. We report a cas...

    Authors: Chia-Ying Chu, Wei-Yu Chen, Shauh-Der Yeh, Huey-Min Yeh and Chia-Lang Fang
    Citation: Diagnostic Pathology 2016 11:4
    Content type: Case Report Published on:

  46. A 55-year-old postmenopausal female presented with genital bleeding and lower abdominal mass. An abdominal MRI revealed a heterogeneously enhanced, 15 × 10 cm mass, completely filling the lumen of the enlarged...

    Authors: Sohsuke Yamada, Yoshikazu Harada, Hirotsugu Noguchi, Naoko Satoh, Satoshi Kimura, Toshiyuki Nakayama and Akihide Tanimoto
    Citation: Diagnostic Pathology 2016 11:3
    Content type: Case Report Published on:

  47. The systemic consequences of esthetic filler injections are poorly understood.

    Authors: Pablo Cannata-Ortiz, Carolina Gracia, Youssef Aouad, Antonio Barat, Miguel Angel Martinez-Gonzalez, Gabriela Rossello, Catalina Martin-Cleary, Beatriz Fernández-Fernández, Luis Requena and Alberto Ortiz
    Citation: Diagnostic Pathology 2016 11:2
    Content type: Case Report Published on:

  48. Diagnostic cytopathology is an essential part of clinical decision-making. However, due to a combination of factors including curriculum reform and shortage of pathologists to teach introductory cytopathology,...

    Authors: Simone L. Van Es, Rakesh K. Kumar, Wendy M. Pryor, Elizabeth L. Salisbury and Gary M. Velan
    Citation: Diagnostic Pathology 2016 11:1
    Content type: Research Published on:

  49. Rheumatoid Arthritis is a chronic disease leading to decreased quality of life with a rather variable response rate to Disease Modifying Anti Rheumatic Drugs. Methotrexate (MTX) is the gold standard therapy in...

    Authors: Tamás Micsik, András Lőrincz, János Gál, Richard Schwab and István Peták
    Citation: Diagnostic Pathology 2015 10:216
    Content type: Research Published on:

  50. Discordant lymphoma is defined by the simultaneous presence of two or more distinct types of lymphomas at different anatomic sites. With fewer than 20 studies reporting cases of discordant lymphoma to date, th...

    Authors: Chun Zhang, Yuanxue Yi, Chunyan Chen, Jianrong Wang and Zhu Liu
    Citation: Diagnostic Pathology 2015 10:215
    Content type: Case Report Published on:
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Diagnostic Pathology

ISSN: 1746-1596

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