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COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

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  1. Currently, breast cancers are divided into four major molecular subtypes. The distinction between the luminal A and luminal B subtypes is mainly based on the cellular proliferation indices and is assessed by t...

    Authors: Dorsay Sadeghian, Hana Saffar, Pouya Mahdavi Sharif, Vahid Soleimani and Behnaz Jahanbin
    Citation: Diagnostic Pathology 2022 17:24
    Content type: Research Published on:

  2. The incidence of tongue cancer in young adults is on the rise. This trend is more pronounced in females. Although the aetiology is still unclear, there is mounting evidence that genetic syndromes can play a ke...

    Authors: Takako Eva Yabe, Kylie King, Susan Russell, Laveniya Satgunaseelan, Ruta Gupta, James Chen and Bruce Ashford
    Citation: Diagnostic Pathology 2022 17:23
    Content type: Case Report Published on:

  3. SWItch Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex functions collectively as a tumor suppressor and the inactivation of any of its constituent components is frequently associated with tumor ...

    Authors: Wenjuan Xu, Haiying Dong, Guoqing Ru and Ming Zhao
    Citation: Diagnostic Pathology 2022 17:22
    Content type: Case Report Published on:

  4. Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a strong cancer stem cell marker in colorectal cancer; however, there are many unclear aspects of LGR5 expression in pancreatic cancer. It has...

    Authors: Masato Kamakura, Takeshi Uehara, Mai Iwaya, Shiho Asaka, Shota Kobayashi, Tomoyuki Nakajima, Yasuhiro Kinugawa, Tadanobu Nagaya, Takahiro Yoshizawa, Akira Shimizu, Hiroyoshi Ota and Takeji Umemura
    Citation: Diagnostic Pathology 2022 17:21
    Content type: Research Published on:

  5. Ki-67 standard reference card (SRC) and artificial intelligence (AI) software were used to evaluate breast cancer Ki-67LI. We established training and validation sets and studied the repeatability inter-observ...

    Authors: Lina Li, Dandan Han, Yongqiang Yu, Jinze Li and Yueping Liu
    Citation: Diagnostic Pathology 2022 17:20
    Content type: Research Published on:

  6. Fibro-adipose vascular anomaly (FAVA) is a rare and new entity of vascular anomaly. Activating mutations in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene were identified...

    Authors: Yumiko Hori, Katsutoshi Hirose, Michio Ozeki, Kenji Hata, Daisuke Motooka, Shinichiro Tahara, Takahiro Matsui, Masaharu Kohara, Hiroki Higashihara, Yusuke Ono, Kaishu Tanaka, Satoru Toyosawa and Eiichi Morii
    Citation: Diagnostic Pathology 2022 17:19
    Content type: Short report Published on:

    The Correction to this article has been published in Diagnostic Pathology 2022 17:43

  7. As a rare salivary gland malignancy, clear cell carcinoma (CCC) is easily misdiagnosed. This study identified the features that allow better recognition of the clinicopathological and molecular characteristics...

    Authors: Lanlan Xuan, Suxia Wang, Jianguo Wei, Jianwei Yuan and Honggang Liu
    Citation: Diagnostic Pathology 2022 17:18
    Content type: Research Published on:

  8. Immunohistochemistry (IHC) using monoclonal and polyclonal antibodies is a useful diagnostic method for detecting pathogen antigens in fixed tissues, complementing the direct diagnosis of infectious diseases b...

    Authors: Hamadou Oumarou Hama, Gérard Aboudharam, Rémi Barbieri, Hubert Lepidi and Michel Drancourt
    Citation: Diagnostic Pathology 2022 17:17
    Content type: Review Published on:

  9. The human amphoterin-induced gene and open reading frame (AMIGO) was identified as a novel cell adhesion molecule of type I transmembrane protein. AMIGO2 is one of three members of the AMIGO family (AMIGO1, 2,...

    Authors: Keisuke Goto, Mitsuhiko Osaki, Runa Izutsu, Hiroshi Tanaka, Ryo Sasaki, Akimitsu Tanio, Hiroyuki Satofuka, Yasuhiro Kazuki, Manabu Yamamoto, Hiroyuki Kugoh, Hisao Ito, Mitsuo Oshimura, Yoshiyuki Fujiwara and Futoshi Okada
    Citation: Diagnostic Pathology 2022 17:16
    Content type: Short report Published on:

  11. Currently, FLT3 internal tandem duplication (ITD) is tested by fragment analysis. With next-generation sequencing (NGS), however, not only FLT3 ITD but also other mutations can be detected, which can provide more...

    Authors: Jin Ju Kim, Kwang Seob Lee, Taek Gyu Lee, Seungjae Lee, Saeam Shin and Seung-Tae Lee
    Citation: Diagnostic Pathology 2022 17:14
    Content type: Research Published on:

  12. STAT3 plays an important role in cervical cancer. LC3B, the most potential molecular biomarker of autophagy that may promote or inhibit cancer progression, can be downregulated by STAT3. However the role of ST...

    Authors: Lin Wu, Bowen Shen, Junpeng Li, Huirong Zhang, Ke Zhang, Yao Yang, Zhenyu Zu, Dongxiang Shen and Min Luo
    Citation: Diagnostic Pathology 2022 17:13
    Content type: Research Published on:

  13. The aim of this study was to evaluate the clinicopathological factors and prognosis of mucinous carcinoma (MC) with infiltrative invasion, MC with expansile invasion, and high-grade serous carcinoma (HGSC).

    Authors: Taira Hada, Morikazu Miyamoto, Hiroki Ishibashi, Hiroko Matsuura, Soichiro Kakimoto, Hideki Iwahashi, Hitoshi Tsuda and Masashi Takano
    Citation: Diagnostic Pathology 2022 17:12
    Content type: Research Published on:

  14. Hepatitis B Virus (HBV) infection is the major risk factor for hepatocellular carcinoma (HCC) in East Asia. Here we aimed to further investigate the abundance of viral antigen and DNA within HBV-related HCC an...

    Authors: Ye Zheng, Mingzhu Xu, Dong Zeng, Haitao Tong, Yuhan Shi, Yanling Feng and Xiaonan Zhang
    Citation: Diagnostic Pathology 2022 17:11
    Content type: Research Published on:

  15. UPK2 exhibits excellent specificity for urothelial carcinoma (UC). UPK2 evaluation can be useful in making the correct diagnosis of UC. However, UPK2 detection by immunohistochemistry (IHC) has relatively low ...

    Authors: Jiangli Lu, Ming Zhao, Chenyan Wu, Chengbiao Chu, Chris Zhiyi Zhang and Yun Cao
    Citation: Diagnostic Pathology 2022 17:10
    Content type: Research Published on:

  16. Cytomegalovirus (CMV) has been recognized as one of the frequently occurring opportunistic infections (OIs) reported in the patients having human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/...

    Authors: Lei Sun, Jia-min Chen, Kun Yang, Liang Zhang, Zhi-yuan Ma, Xiang-mei Chen, Man Li, Xingang Zhou, Ping Li, Hong-xin Zhao, Jiang Xiao, Li-ming Qi and Peng Wang
    Citation: Diagnostic Pathology 2022 17:9
    Content type: Research Published on:

  17. Yolk sac tumor (YST) is a germ cell tumor. It is primarily located in the gonads but can also occur extragonadally (extragonadal yolk sac tumor - EGYST), most commonly in the pelvis, retroperitoneum or mediast...

    Authors: Vladimír Šámal, Tomáš Jirásek, Vít Paldus, Igor Richter and Ondřej Hes
    Citation: Diagnostic Pathology 2022 17:8
    Content type: Case Report Published on:

  18. A number of biomarkers have the potential of differentiating between primary lung tumours and secondary lung tumours from the gastrointestinal tract, however, a standardised panel for that purpose does not exi...

    Authors: Bachar Alabdullah and Amir Hadji-Ashrafy
    Citation: Diagnostic Pathology 2022 17:7
    Content type: Research Published on:

  19. Desmoplastic small round cell tumor (DSRCT) is a sporadic, highly malignant tumor with a poor prognosis. The abdomen and pelvis have been reported as the primary localization sites. However, to the best of our...

    Authors: Jiayu Zhou, Qingling Li, Baihua Luo, Xiaodan Fu, Chunlin Ou, Xiaomei Gao, Zhijie Xu, Deyun Feng and Keda Yang
    Citation: Diagnostic Pathology 2022 17:6
    Content type: Case Report Published on:

  20. According to 2018 ASCO/CAP guideline, HER2 FISH-equivocal breast cancers will be categorized as HER2 negative except those with IHC 3+. However, whether or not HER2 FISH-equivocal breast cancers was a heteroge...

    Authors: Hui Kong, Qianming Bai, Anqi Li, Xiaoyan Zhou and Wentao Yang
    Citation: Diagnostic Pathology 2022 17:5
    Content type: Research Published on:

  21. NUT (nuclear protein in testis) midline carcinoma (NMC) is a rapidly progressive tumor arising from midline structures. Recent cases have reported that the poor prognosis with a median survival of 6.7 months a...

    Authors: Jin Jiang, Yikun Ren, Chengping Xu and Xing Lin
    Citation: Diagnostic Pathology 2022 17:4
    Content type: Case Report Published on:

  22. Immunodeficient patients, including the recipients of solid organs, exhibit an increase in the incidence of neoplasms. Post-transplant smooth muscle tumor (PTSMT) is a distinct and infrequent entity of these g...

    Authors: Mohammad Hossein Anbardar, Neda Soleimani, Dornaz Safavi, Ahad Eshraghian and Abbas Ayoub
    Citation: Diagnostic Pathology 2022 17:3
    Content type: Case Report Published on:

  23. Synaptophysin (SYN), chromogranin A (CGA), CD56 and insulinoma-associated protein 1 (INSM1) are proposed neuroendocrine (NE) markers used for diagnosis of pulmonary NE tumors. These NE markers have been identi...

    Authors: Lu Yu, Yuting Dong, Jin Xue, Sanpeng Xu, Guoping Wang, Dong Kuang and Yaqi Duan
    Citation: Diagnostic Pathology 2022 17:2
    Content type: Research Published on:

  25. Pseudomyxoma peritonei (PMP) is a complex and partially understood disease defined by mucin deposits in the peritoneal cavity, mostly of appendiceal origin caused by the rupture of a mucocele often containing ...

    Authors: Marie Csanyi-Bastien, France Blanchard, Aude Lamy and Jean-Christophe Sabourin
    Citation: Diagnostic Pathology 2021 16:119
    Content type: Case Report Published on:

  26. Transmission of malignancy is a notable problem that cannot always be absolutely predicted at the time of transplantation. In particular, donor-derived transmission of synovial sarcoma in solid-organ transplan...

    Authors: Jian Zhang, Yang Yang, Ye Tian, Ruifang Xu and Jun Lin
    Citation: Diagnostic Pathology 2021 16:118
    Content type: Case Report Published on:

  27. Pancreatic medullary carcinoma (PMC) is a rare pancreatic tumor, usually showing the presence of microsatellite instability, mostly MLH1 silencing, and a wild-type KRAS mutation status. We report here a PMC ar...

    Authors: Camille Verocq, Marie-Lucie Racu, Dominique Bafort, Gloria Butorano, Luis Perez-Casanova Garcia, Julie Navez, Marc Witterwulghe, Kieran Sheahan, Niall Swan, Jean Closset, Jean-Luc Van Laethem, Calliope Maris and Nicky D’Haene
    Citation: Diagnostic Pathology 2021 16:117
    Content type: Case Report Published on:

  28. As a rare clinical tumor syndrome with an indolent clinical course and lack of pathognomonic symptoms, pseudomyxoma peritonei (PMP) is usually diagnosed at an advanced stage. In-depth pathological analysis is ...

    Authors: Ru Ma, Yu-Lin Lin, Xin-Bao Li, Feng-Cai Yan, Hong-Bin Xu, Zheng Peng and Yan Li
    Citation: Diagnostic Pathology 2021 16:116
    Content type: Research Published on:

  29. Synovial sarcomas are a rare type of high-grade sarcomas with unknown cell origin. They arise predominantly in the soft tissues but rarely in the stomach. We recently encountered a rare case of minute gastric ...

    Authors: Kanako Yoshiyasu, Hiroshi Kono, Yudai Hojo, Yoshinori Ishida, Akio Tamura, Keisuke Nakai, Tadayuki Oshima, Hiroto Miwa, Hisashi Shinohara and Seiichi Hirota
    Citation: Diagnostic Pathology 2021 16:115
    Content type: Case Report Published on:

  30. Monomorphic epitheliotropic T-cell lymphoma (MEITL) is an aggressive non-Hodgkin lymphoma with a high fatality rate. This study was aimed to explore the clinicopathological and molecular genetic features of ME...

    Authors: Chunni Chen, Yuxi Gong, Yefan Yang, Qiuyuan Xia, Qiu Rao, Yang Shao, Liuqing Zhu, Junli Zhang, Xiao Li, Pan Ji, Boya Zhai, Xiang Zhang and Zhihong Zhang
    Citation: Diagnostic Pathology 2021 16:114
    Content type: Research Published on:

  31. Many studies reporting that down-regulation of SOCS6 plays vital roles in promoting progression of malignant tumors have been published. The present study was performed to evaluate whether SOCS6 was significan...

    Authors: Jun Ouyang, Tailai An, Yan Wang, Xiaofang Lu, Yawei Zhang, Xiaokun Wang, Xinhua Zhang and Changhua Zhang
    Citation: Diagnostic Pathology 2021 16:113
    Content type: Research Published on:

  33. Endoscopic submucosal dissection (ESD) is a novel endoscopic treatment for early esophageal adenocarcinoma (EAC). The western pathologists’ experience with ESD specimens remains limited. This study aimed to co...

    Authors: Sadhna Dhingra, Firas Bahdi, Sarah B. May and Mohamed O. Othman
    Citation: Diagnostic Pathology 2021 16:111
    Content type: Research Published on:

  34. Immunotherapy is an important treatment in oncology, but only a fraction of patients with head and neck squamous cell carcinoma (HNSCC) benefit from it. Therefore, the aim of this study was to identify predict...

    Authors: Xuanli Xu, Rongrong Li, Lin Zhang, Guopei Zhu, Dandan Ren, Lijia Wu and Xiaoli Gong
    Citation: Diagnostic Pathology 2021 16:110
    Content type: Research Published on:

  35. Lymphovascular invasion (VI) is an established prognostic marker for many cancers including bladder cancer. There is a paucity of data regarding whether the prognostic significance of lymphatic invasion (LVI) ...

    Authors: Birgitte Carlsen, Tor Audun Klingen, Bettina Kulle Andreassen and Erik Skaaheim Haug
    Citation: Diagnostic Pathology 2021 16:109
    Content type: Research Published on:

  36. Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) of the pancreas are extremely rare. Their pathogenesis and molecular landscape are largely unknown. Here, we report a case of mixed pancreatic intraduc...

    Authors: Jingci Chen, Pengyan Wang, Ke Lv and Weixun Zhou
    Citation: Diagnostic Pathology 2021 16:108
    Content type: Case Report Published on:

  37. Hereditary papillary renal cell carcinoma (HPRCC) is a rare autosomal dominant disease characterized by the development of multiple and bilateral papillary type I renal cell carcinomas (RCC) and papillary aden...

    Authors: Sophie Ferlicot, Pierre-Alexandre Just, Eva Compérat, Etienne Rouleau, Frédérique Tissier, Christophe Vaessen and Stéphane Richard
    Citation: Diagnostic Pathology 2021 16:107
    Content type: Case Report Published on:

  38. Microsatellite instability occurs due to a series of mutations in the DNA pairing error repair (Mismatch repair; MMR) genes, which can affect germ cells as occurs in Lynch syndrome, whose patients are at high ...

    Authors: Eduardo Sobrino-Reig, Telma Meizoso, Jesús García, David Varillas-Delgado and Yasmina B. Martin
    Citation: Diagnostic Pathology 2021 16:106
    Content type: Research Published on:

  39. Cervical cancer (CC) endangers women’s health in the world range. Accumulating studies have revealed the crucial regulatory role of long non-coding RNAs (lncRNAs) in multiple malignancies, including CC. Our st...

    Authors: Jihui Gu, Yi Liu, Ting Qi, Weiwei Qian, Dongdong Hu and Wen Feng
    Citation: Diagnostic Pathology 2021 16:105
    Content type: Research Published on:

  41. We present a unique case of primary breast CD20-positive extranodal NK/T cell lymphoma with stomach involvement in a young Chinese female patient.

    Authors: Ying Zhang, Kuansong Wang, Qian Tan, Keda Yang, Dengshu Wu, Yajing Xu, Xielan Zhao and Zhiping Jiang
    Citation: Diagnostic Pathology 2021 16:103
    Content type: Case Report Published on:

  42. Detection of the tumor-specific EWSR1/FUS-ETS fusion gene is essential to diagnose Ewing sarcoma. Reverse transcription–polymerase chain reaction (RT–PCR) and fluorescence in situ hybridization are commonly used ...

    Authors: Hitomi Ueno-Yokohata, Hajime Okita, Keiko Nakasato, Chikako Kiyotani, Motohiro Kato, Kimikazu Matsumoto, Nobutaka Kiyokawa, Atsuko Nakazawa and Takako Yoshioka
    Citation: Diagnostic Pathology 2021 16:102
    Content type: Research Published on:

  43. The clinicopathological characteristics and prognostic factors in nodal peripheral T-cell lymphomas (PTCLs) with two or more T follicular helper markers (TFH+) are not adequately investigated.

    Authors: Yasuhito Mihashi, Shoichi Kimura, Hiromi Iwasaki, Yumi Oshiro, Yasushi Takamatsu, Shigeto Kawauchi, Shohei Shimajiri, Kenji Ishizuka and Morishige Takeshita
    Citation: Diagnostic Pathology 2021 16:101
    Content type: Research Published on:

  44. TP53 mutation is found frequently in therapy related acute myeloid leukemia (AML)/ myelodysplastic syndrome (MDS), AML and MDS patients with monosomy or complex karyotype. However, the prevalence and treatment...

    Authors: Pimjai Niparuck, Pornnapa Police, Phichchapha Noikongdee, Kanchana Siriputtanapong, Nittaya Limsuwanachot, Budsaba Rerkamnuaychoke, Suporn Chuncharunee and Teerapong Siriboonpiputtana
    Citation: Diagnostic Pathology 2021 16:100
    Content type: Research Published on:

  45. Extraosseous benign notochordal cell tumor is extremely rare, and there are only five reported cases worldwide. The presented case of pulmonary primary benign notochordal cell tumor is the sixth case, but the ...

    Authors: Kai Song, Xiaojing Ma, Jinghong Xu and Lirong Chen
    Citation: Diagnostic Pathology 2021 16:99
    Content type: Case Report Published on:

  46. Aurora-A kinase is important for cellular proliferation and is implicated in the tumorigenesis of several malignancies, including of the ovary. Information regarding the expression patterns of Aurora-A in norm...

    Authors: Khaled J. Alkhateeb, Jason E. Crane, Müge Sak, Caitlin J. Jorgensen, James P. O’Donnell, Cory T. Zumbar, Jason A. Wozniak, Clarence R. Salazar, Anil V. Parwani and Norman L. Lehman
    Citation: Diagnostic Pathology 2021 16:98
    Content type: Research Published on:

  47. Adult-onset Still’s disease (AOSD) often presents with systemic multiple lymphadenopathy. In addition to the common paracortical and mixed patterns in AOSD lymph node histopathological features, other morpholo...

    Authors: Zhonghua Huang, Hua Xu, Qinqin Min, Zhenguo Li, Jiaxin Bi, Lingyun Liu and Yingying Liang
    Citation: Diagnostic Pathology 2021 16:97
    Content type: Case Report Published on:

  48. The fibroblast growth factor receptor substrate 2 (FRS2) gene is located close to MDM2 and CDK4 within the 12q13-15 chromosomal region. FRS2 gene was recently found to be consistently amplified in atypical lipoma...

    Authors: Wenyi Jing, Ting Lan, Yan Qiu, Ran Peng, Yang Lu, Huijiao Chen, Min Chen, Xin He, Chen Chen and Hongying Zhang
    Citation: Diagnostic Pathology 2021 16:96
    Content type: Research Published on:

  49. The precursors of clear cell endometrial carcinoma (CC-EC) are still undefined. Here, we deal with the diagnostic issues related to CC-EC precursors by presenting a morphological, immunophenotypical and molecu...

    Authors: Angela Santoro, Antonio Travaglino, Frediano Inzani, Damiano Arciuolo, Giuseppe Angelico, Nicoletta D’Alessandris, Giulia Scaglione, Michele Valente, Maurizio Martini, Antonio Raffone and Gian Franco Zannoni
    Citation: Diagnostic Pathology 2021 16:95
    Content type: Case Report Published on:

  50. Immune checkpoint proteins, especially PD-L1 and PD-1, play a crucial role in controlling the intensity and duration of the immune response, thus preventing the development of autoimmunity. These proteins play...

    Authors: Mohammed Akhtar, Sameera Rashid and Issam A. Al-Bozom
    Citation: Diagnostic Pathology 2021 16:94
    Content type: Review Published on:

    The Correction to this article has been published in Diagnostic Pathology 2022 17:50

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Diagnostic Pathology

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