- Case Report
- Open Access
Coexistence of pulmonary sclerosing hemangioma and primary adenocarcinoma in the same nodule of lung
© Liu et al; licensee BioMed Central Ltd. 2011
- Received: 19 April 2011
- Accepted: 20 May 2011
- Published: 20 May 2011
Pulmonary sclerosing hemangiomas (PSH) of the lung are uncommon tumors and may present cytological atypia with unusual manifestations. The development of PSH combined with other different tumors in lung is extremely rare. We report a case of coexistence of PSH and primary adenocarcinoma in a young female occurring in the same pulmonary nodular mass of right lower lobe. The solitary mass of lung was well-circumscribed on chest computed tomography (CT) and gross examination. Histologically, the mass contained two separated portions and displayed typically histological features of PSH and acinar adenocarcinoma, respectively. In PSH portion, the tumor was composed of sheets of round cells with scattered surface cuboidal cells forming small tubules. Both round and surface cells were diffusely positive for epithelial membrane antigen (EMA) and thyroid transcription factor-1 (TTF-1), but lack immunoreactivity for pancytokeratin in round cells. In adenocarcinoma portion, the tumor cells formed irregular-shaped glands with cytologically malignant cells infiltrating in fibroblastic stroma, and no TTF-1-positive round cells could be observed in this portion. Under the microscopy, there was no gradual transition of these two portions observed in mass. A diagnosis of PSH combined with primary adenocarcinoma of lung was made. There was no evidence of tumor recurrence during the period of postoperative 6-month follow-up. To our knowledge, this is the first case of coexistence of PSH and adenocarcinoma in the same nodule of lung. In addition, the biological behavior and histological differential diagnosis of this tumor were also discussed.
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- Round Cell
- Epithelial Membrane Antigen
- Primary Adenocarcinoma
- Atypical Adenomatous Hyperplasia
- Nodular Mass
Pulmonary sclerosing hemangioma (PSH) is an uncommon tumor and is thought to be a benign neoplasm of lung [1, 2]. However, histogenesis and biological behavior of this tumor has not yet been clarified adequately. Histologically, the characteristics of PSH have been well-described as papillary, solid, sclerotic, or hemorrhagic patterns. PSH comprises two well-accepted cell types: eosinophilic cuboidal epithelial lining cells and round cells with either eosinophilic or clear cytoplasm . Although most PSH cases have a mixture of these four histological patterns with two cell types, unusual morphological presentations have been revealed in a few cases, such as atypical adenomatous hyperplasia or adenocarcinoma-like area within the PSH . However, to our knowledge, so far there is no report to describe a coexistence of PSH and primary adenocarcinoma within the same lobe of lung in English literatures. Herein we report a young female with PSH combined with adenocarcinoma in the same nodule of right lower lobe. Histopathological findings and imaging features, as well as outcome and differential diagnosis are to be discussed.
The term of "pulmonary sclerosing hemangioma (PSH)" was first used in 1956 by Liebow and Hubbell, in which sclerosing hemangioma was described as a variant of hemangioma due to prominent angiomatoid features and occurred predominantly in young or middle-aged women . In 1981, WHO classification of lung tumors accepted PSH as a tumor-like lesion . However, the histogenesis of PSH has not yet been elucidated since it first description. Subsequent studies have postulated that PSH might originate from mesothelium , mesenchyma , epithelium , and neuroendocrine cells . Recent immunohistochemical studies revealed that PSH might derive from primitive undifferentiated respiratory epithelium [9, 10], and molecular study has also demonstrated the same monoclonal pattern in both the round and surface cells, consistent with a ture neoplasm rather than a hamartoma . Therefore, the PSH was categorized as a miscellaneous tumor of lung in 1999 and 2004 WHO classification of lung tumors [2, 12].
In the current study, we found that both surface and round cells in PSH portion of mass were immuno-positive for TTF-1 and EMA, but round cells were negative for pancytokeratin. These results provided useful clues not only for histogenesis but also for the diagnosis of this tumor. However, in contrast to most previous studies, the focal weak positivity of round cells, but not surface cells, for neuroendocrine marker, synaptophysin (Syn) was found in our case. This result indicated that tumor cells in PSH, in particular round cells, might have potential to neuroendocrine differentiation or represent incompletely differentiated Clara cells. It is well known that TTF-1 expressed in the non-ciliated columnar cells of the fetal lung as early as 11 weeks of gestation, and in type II pneumocytes and Clara cells of the adult lung [13, 14], and both surface cells and round cells of PSH represented a variable differentiation from a common progenitor cell . In the present case, the immunohistochemical positivity of round cells for TTF-1 and Syn supported that these cells were derived from a primitive respiratory cell, and part of round cells might be intermediate differentiation between undifferentiated primitive respiratory cell and differentiated Clara cells or pneumocytes [9, 10]. That might be the reason why typical carcinoid could be generated from PSH . Of course, larger series should be performed to verify this postulation.
PSH is a distinctive lung tumor, which is composed of mixtures of papillary, solid, sclerotic, and/or hemorrhagic patterns with varying proportions of two cell types. Variable degrees of cytologic atypia were found in most PSH. The cases of atypical alveolar hyperplasia (AAH) in PSH , alveolar adenoma with PSH , and transition from atypical hyperplasia of type II pneumocyte to PSH  have been described in literatures. Recently, a case of alveolar adenoma-like area in the peripheral portion of the PSH, and a case of papillary adenocarcinoma-like area within the PSH have also been reported . These findings suggested that AAH of type II pneumocytes could be a focus of atypical growth of lining epithelial cells of PSH, or AAH- and adenocarcinoma-like lesion with papillae might be presumptive precursor lesion of PSH. However, in contrast to previous studies, in our case we found acinar adenocarcinoma coexisted with PSH in the same nodular mass. We wondered if this adenocarcinoma portion of mass was a substantive primary tumor or just a subordinate adenocarcinoma-like area within the PSH. We reviewed the histological and immunohistochemical features of unusual presentations within the PSH in securable literatures. We found that (a) a gradual transition from unusual structures, including AAH, avleolar adenoma-like area and adenocarcinoma-like area, to the majority of PSH could be observed in all reported cases; (b) TTF-1 positive round cells could be detected in varied amount in the interstitial portion of unusual structures. However, in the present case, adenocarcinoma portion and PSH portion were separated distribution without gradual transition area under the microscopical examination by serial section, and there was no TTF-1 positive round cells found in the fibroblastic stroma of adenocarcinoma. Based on those findings, we considered the adenocarcinoma portion was a true primary tumor rather than an unusual histological presentation of PSH. Existence of adenocarcinoma and PSH in different segmental nodular mass of pulmonary lobe has been described . But to our knowledge, ours is the first case to demonstrate the coexistence of adenocarcinoma and PSH within the same nodule of lung.
PSH is a clinically benign tumor and has a good prognosis after surgical resection. However, lymph node metastasis and multifocal distribution of PSH have been found in a few cases [3, 15, 16, 20, 21]. Moreover, moderate to severe cytological atypia, and sometimes combined with unusual structures, might make PSH like a malignancy. The main histological differential diagnosis includes papillary alveolar adenoma, bronchioloalveolar carcinoma, carcinoid, and papillary adenocarcinoma, all of which exhibit papillary, solid or tubular appearance and may sometimes cause diagnostic confusion with PSH, especially in insufficient biopsy specimen. However, the papillary-like structure in PSH is not true papillae, which is composed of lining cuboidal cells and round cells below rather than fibrovascular cores present in other tumors with true papillary structure. The presence of pale round cells in tumor and immuno-positivity of round cells for TTF-1, EMA and ER, PR support the diagnosis of PSH. There are histological similarities between carcinoid and PSH when PSH displays solid histological pattern predominantly, in which uniform round cells are arranged in sheets pattern. But lack of strong diffuse TTF-1 reactivity may also be useful in excluding carcinoid. Together with histological features, immunohistochemical evaluation with a panel of EMA, pancytokeratin and TTF-1 is most useful in distinguishing PSH from other similar tumors.
We herein first reported a rare case of PSH combined with primary adenocarcinoma occurred in the same nodular mass of lung. The mass contained two separated portions and displayed typically histological features of PSH and adenocarcinoma, respectively. The precise mechanism of coexistence of PSH and adenocarcinoma in the same nodule remains unknown, and longer period of follow-up and more case investigation are necessary to better clarify the biological characteristics and clinical outcomes of this unusual tumor.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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